Synthesis and antibacterial activity of C-2 carboxyethenylthio-carbapenem derivatives
| Autor: | Steven Coulton, Robert Southgate, David F. Corbett, Michael J. Basker |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Carbapenem
Chemical Phenomena Stereochemistry Molecular Conformation Stereoisomerism Biology Kidney Chemical synthesis Mice Drug Stability Culture Techniques Drug Discovery medicine Animals Humans Escherichia coli Infections Antibacterial agent Pharmacology Bacteria Molecular Structure Kidney metabolism Biological activity Staphylococcal Infections In vitro Chemistry Carbapenems Antibacterial activity medicine.drug |
| Zdroj: | The Journal of Antibiotics. 43:847-857 |
| ISSN: | 1881-1469 0021-8820 |
| Popis: | A number of C-2 carboxyethenylthio-carbapenem derivatives possessing either the (5R,6R,8S)- or the (5R,6S,8R)-stereochemistries have been prepared from the olivanic acids MM 22382 (1) and MM 22383 (4), respectively. Their in vitro antibacterial activities and stabilities to human kidney homogenate are superior to those of the parent compounds, particularly in the latter series. |
| Databáze: | OpenAIRE |
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