Premature Centromere Division Dominantly Inherited in a Subfertile Family
| Autor: | J. Gabarrón, G. Glover, A. Jimenez |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Proband medicine.medical_specialty PREMATURE CENTROMERE DIVISION Lymphocyte Centromere Biology Chromosomes chemistry.chemical_compound Genetics medicine Humans Colchicine Lymphocytes Molecular Biology Mitosis Genetics (clinical) Cells Cultured Genes Dominant Cytogenetics Obstetrics and Gynecology Chromosome General Medicine Fibroblasts Cell cycle Molecular biology medicine.anatomical_structure chemistry Karyotyping Female Ploidy Infertility Female |
| Zdroj: | Obstetrical & Gynecological Survey. 42:523-524 |
| ISSN: | 0029-7828 |
| DOI: | 10.1097/00006254-198708000-00018 |
| Popis: | An increased frequency of mitoses showing premature centromere division (PCD) in every chromosome was found in lymphocyte cultures from four members of a subfertile family. These cells were observed in both the presence and absence of colchicine. Cultured fibroblasts from the proband showed only normal diploid metaphases. PCD cells seemed to have a shorter cell cycle. The anomaly was transmitted in a way compatible with autosomal dominant inheritance in this family. |
| Databáze: | OpenAIRE |
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