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Gruzevsky A. A., Zyablitsev S. V., Chernobrivtsev P. A. Frequency of vaginal conditional-pathogenic microflora dependency from age in conditions of normocenosis and disbiosis. Journal of Education, Health and Sport. 2017;7(2):509-522. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.399315 http://ojs.ukw.edu.pl/index.php/johs/article/view/4360 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.02.2017. Revised 24.02.2017. Accepted: 27.02.2017. UDK 618.15-002:616-093-/098 FREQUENCY OF VAGINAL CONDITIONAL-PATHOGENIC MICROFLORA DEPENDENCY FROM AGE IN CONDITIONS OF NORMOCENOSIS AND DISBIOSIS A. A. Gruzevsky, S. V. Zyablitsev, P. A. Chernobrivtsev Odessa National Medical University, Odessa Summary 298 patients aged 16-64 years were examined who excluded the presence of pathogenic microflora; Polymerase chain reaction (PCR) in real time investigated the biocenosis of the vagina. Depending on the value of the index of opportunistic microflora, the patients were divided into three groups: normocenosis, imbalance I and II degree (dysbiosis). In each group age subgroups were distinguished: from 16 to 25 years, from 26 to 45 years and over 45 years. It is shown that with age and with the increase in the degree of dysbiosis the total bacterial mass and the population of the vagina decreased by lactobacilli. Normocenosis is characterized by a constant occurrence of enterobacteria, an increase in the incidence of candida with age, Eubacterium spp. And Mobiluncus spp. + Corynebacterium spp. In general, Sneathia spp. + Leptotrihia spp. + Fusobacterium spp. And Mycoplasma hominis + genitalium. With the 1st degree disbiosis the incidence of enterobacteria, Candida and Ureaplasma urealiticum + parvum decreased with age, with more frequent occurrence of staphylococci, Megasphaera spp. + Veilonella spp. + Dialister spp. аnd Lachnobacterium spp. + Clostridium spp. The 2nd degree of dysbiosis was characterized by the disappearance of streptococci with age and a decrease in the number of Eubacterium spp. (In patients older than 45 years), an increase in the frequency of obligate anaerobes, especially Mobiluncus spp. + Corynebacterium spp. and Atopobium vaginalis. Mycoplasma hominis + genitalium appeared in the middle age group (26-45 years). Key words: vaginal dysbiosis, facultative and obligate anaerobes, mycoplasmas, candidas |
