Improvement in dyslipidaemia after switching stavudine to tenofovir and replacing protease inhibitors with efavirenz in HIV-infected children
| Autor: | Silvia Beretta, Laura Martelli, Stefano Mora, Marzia Merlo, Vania Giacomet, Paola Luraschi, Grace M. Aldrovandi, Alessandra Viganò, Giuseppe Rombolà |
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| Rok vydání: | 2006 |
| Předmět: |
Cyclopropanes
Male Efavirenz Adolescent Anti-HIV Agents medicine.medical_treatment Organophosphonates HIV Infections chemistry.chemical_compound Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active Oxazines medicine Humans Pharmacology (medical) Protease inhibitor (pharmacology) Protease Inhibitors Sida Child Tenofovir Dyslipidemias Pharmacology Protease biology Reverse-transcriptase inhibitor Adenine Stavudine Viral Load biology.organism_classification medicine.disease Virology Lipids Benzoxazines CD4 Lymphocyte Count Infectious Diseases Treatment Outcome chemistry Alkynes HIV-1 Female Viral disease medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1359-6535 |
| Popis: | Objective To assess the impact on immunological, virological and metabolic parameters of replacing protease inhibitors (PIs) with efavirenz and replacing stavudine with tenofovir in HIV-infected children. Methods A 48-week prospective evaluation of 28 HIV-infected children, with stable undetectable HIV-1 loads, who were taking highly active antiretroviral therapy (HAART) containing lamivudine, stavudine and a PI. Individuals were randomized to switch PI to efavirenz and stavudine to tenofovir at baseline (Group 1) or at week 24 (Group 2). Patient assessment included: clinical evaluation, viral load, CD4+ T-cell count, fasting blood levels and urine samples. Results All individuals maintained HIV RNA + T-cell count through week 48. In Group 1 individuals, a significant decrease in cholesterol ( PConclusions In HIV-infected children, switching PI to efavirenz and stavudine to tenofovir is virologically and immunologically safe, is not associated with renal impairment and provides a significant improvement in lipid profile. |
| Databáze: | OpenAIRE |
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