Fibrin gel enhances the antitumor effects of chimeric antigen receptor T cells in glioblastoma

Autor:	Edikan A. Ogunnaike, Hongwei Du, Frances S. Ligler, Shawn Hingtgen, Barbara Savoldo, Alain Valdivia, Seema Nandi, Simon Khagi, Ernesto Leon, Gianpietro Dotti, Zhen Gu, Hannah Hudson, Mostafa Yazdimamaghani
Rok vydání:	2021
Předmět:	Multidisciplinary biology Chemistry Immunology SciAdv r-articles medicine.disease Fibrin Chimeric antigen receptor Therapeutic approach biology.protein Cancer research medicine Biomedicine and Life Sciences Research Article Cancer Glioblastoma
Zdroj:	Science Advances
ISSN:	2375-2548
DOI:	10.1126/sciadv.abg5841
Popis:	Description In situ fibrin gel promotes the survival and the biodistribution of CAR-T cells, eliminating residual GBM cells after surgery. Regional delivery of chimeric antigen receptor (CAR) T cells in glioblastoma represents a rational therapeutic approach as an alternative to intravenous administration to avoid the blood-brain barrier impediment. Here, we developed a fibrin gel that accommodates CAR-T cell loading and promotes their gradual release. Using a model of subtotal glioblastoma resection, we demonstrated that the fibrin-based gel delivery of CAR-T cells within the surgical cavity enables superior antitumor activity compared to CAR-T cells directly inoculated into the tumor resection cavity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36d90196dd5632951c9f272a0661263 https://doi.org/10.1126/sciadv.abg5841 Zobrazit plný text záznamu