Thiamine deficiency in patients with B-chronic lymphocytic leukaemia: a pilot study
| Autor: | H Seligmann, R Levi, M Prokocimer, Abraham M. Konijn |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Paraneoplastic Syndromes Chronic lymphocytic leukemia Pilot Projects Malignancy Gastroenterology chemistry.chemical_compound Internal medicine medicine Humans Prospective Studies Prospective cohort study Aged Subclinical infection Aged 80 and over business.industry Thiamine Deficiency food and beverages Original Articles General Medicine Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Malnutrition Leukemia chemistry Immunology Female Thiamine business human activities Thiamine pyrophosphate |
| Zdroj: | Postgraduate Medical Journal. 77:582-585 |
| ISSN: | 1469-0756 0032-5473 |
| Popis: | Malignancy associated primary thiamine deficiency has been documented in several experimental tumours, sporadic clinical case reports, and in a number of patients with fast growing haematological malignancies. Thiamine status was assessed prospectively in 14 untreated B-chronic lymphocytic leukaemia (CLL) patients, and in 14 age matched control patients with non-malignant disease. Patients with any known cause of absolute, relative, or functional thiamine deficiency were excluded. High (>15%) thiamine pyrophosphate effect (TPPE), indicating thiamine deficiency, was found in five out of 14 CLL patients (35.7%) and in none of the controls (p=0.057). Mean (SD) TPPE in the thiamine deficient patients group was 21.6 (3.4)%. In all the patients, thiamine deficiency was subclinical. No correlates for the thiamine deficiency have been found save for an increment of more than 20% in the total leucocyte count over the preceding three months, which was found in all five thiamine deficient patients compared with only one of the nine non-thiamine deficient CLL patients. Thus, CLL patients may be prone to develop primary thiamine deficiency possibly promoted by the increased leucocytes span, which may increase thiamine consumption. Since even subclinical thiamine deficiency may be detrimental to the patient's clinical course, and in view of the theoretical danger of thiamine promoted tumour cell proliferation, further large scale studies are warranted to confirm this observation, and to elucidate the issue of thiamine supplementation to CLL patients. |
| Databáze: | OpenAIRE |
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