Post-Transcriptional Control in the Regulation of Polyhydroxyalkanoates Synthesis
| Autor: | Maria A.M. Reis, Filomena Freitas, Cecília M. Arraiano, João Martins-Lourenço, Alexandra Peregrina |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
2019-20 coronavirus outbreak
Coronavirus disease 2019 (COVID-19) Industrial production Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Science Environmental pollution Review Biology General Biochemistry Genetics and Molecular Biology Polyhydroxyalkanoates Metabolic engineering 03 medical and health sciences scl-PHA Post-transcriptional regulation Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences 030306 microbiology microbiology polyhydroxyalkanoates Paleontology riboregulation 13. Climate action Space and Planetary Science small non-coding RNAs 8. Economic growth mcl-PHA Biochemical engineering post-transcriptional regulation |
| Zdroj: | Life, Vol 11, Iss 853, p 853 (2021) Life |
| ISSN: | 2075-1729 |
| Popis: | The large production of non-degradable petrol-based plastics has become a major global issue due to its environmental pollution. Biopolymers produced by microorganisms such as polyhydroxyalkanoates (PHAs) are gaining potential as a sustainable alternative, but the high cost associated with their industrial production has been a limiting factor. Post-transcriptional regulation is a key step to control gene expression in changing environments and has been reported to play a major role in numerous cellular processes. However, limited reports are available concerning the regulation of PHA accumulation in bacteria, and many essential regulatory factors still need to be identified. Here, we review studies where the synthesis of PHA has been reported to be regulated at the post-transcriptional level, and we analyze the RNA-mediated networks involved. Finally, we discuss the forthcoming research on riboregulation, synthetic, and metabolic engineering which could lead to improved strategies for PHAs synthesis in industrial production, thereby reducing the costs currently associated with this procedure. |
| Databáze: | OpenAIRE |
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