Impact of paced left ventricular dyssynchrony on left ventricular reverse remodeling after cardiac resynchronization therapy
| Autor: | Philippe Ritter, Christophe Scavée, Sibille Lejeune, Sébastien Marchandise, Sylvain Ploux, Jean-Benoît le Polain de Waroux, Anaïs Gauthey, Anne-Catherine Pouleur, Erik Willemen, Joost Lumens, Frits W. Prinzen, Pierre Bordachar, Quentin Garnir, Aurélien Wauters |
|---|---|
| Přispěvatelé: | Biomedische Technologie, RS: Carim - H07 Cardiovascular System Dynamics, Fysiologie, RS: Carim - H06 Electro mechanics |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Cardiac resynchronization therapy cardiac resynchronization therapy heart failure interventricular delay 030204 cardiovascular system & hematology GUIDELINES reverse remodeling PATIENT SELECTION Ventricular Function Left Ventricular Dysfunction Left 03 medical and health sciences 0302 clinical medicine Physiology (medical) Internal medicine ELECTRICAL DELAY medicine Humans Computer Simulation left bundle branch block Prospective Studies 030212 general & internal medicine Ventricular dyssynchrony Aged Aged 80 and over Univariate analysis Ischemic cardiomyopathy Ventricular Remodeling business.industry Left bundle branch block Hemodynamics Models Cardiovascular Recovery of Function Odds ratio Middle Aged medicine.disease Confidence interval Treatment Outcome Heart failure Cardiology HEART-FAILURE Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Electrophysiology, 31(2), 494-502. Wiley |
| ISSN: | 1540-8167 1045-3873 |
| Popis: | Introduction: We investigated whether pacing-induced electrical dyssynchrony at the time of cardiac resynchronization therapy (CRT) device implantation was associated with chronic CRT response. Methods and Results: We included a total of 69 consecutive heart failure patients who received a CRT device. Left (LVp-RVs) and right (RVp-LVs) pacing-induced interlead delays were measured intraoperatively and used to determine if there was paced left ventricular (LV) dyssynchrony, defined as present when LVp-RVs is larger than RVp-LVs. CRT response was defined as a reduction in LV end-systolic volume ≥15%, 6 months after implantation. Paced left ventricular dyssynchrony (PLVD) was associated with ischemic cardiomyopathy (ICM) (χ 2: 8; P =.005) but not with QRS morphology nor with pacing lead positions. In a univariate analysis, PLVD (odds ratio [OR], 6.53; 95% confidence interval [CI], 2.2-18.9; P =.001), atypical left bundle branch block (LBBB) (OR, 3.3; 95% CI, 1.2-9.4; P =.022), and ICM (OR, 5.2; 95% CI, 1.6-17; P =.006) were associated with nonresponse. In a multivariate analysis, both PLVD (OR, 9.74; 95% CI, 2.8-33.9; P 2 to enter: 8; P |
| Databáze: | OpenAIRE |
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