Humoral and neurogenic factors in two-kidney renovascular hypertension
| Autor: | Alberto C. Taquini, I J de la Riva, Maria Luisa Kurnjek, Nidia Basso |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Hypertension Renal Physiology Ganglionic Blockers Blood Pressure Pentolinium Pentolinium Tartrate Biochemistry Renovascular hypertension chemistry.chemical_compound Two kidney Bolus (medicine) Internal medicine Renin medicine Animals Infusions Parenteral Kidney business.industry Angiotensin II medicine.disease Rats Hypertension Renovascular medicine.anatomical_structure Endocrinology Blood pressure chemistry Anesthesia Saralasin business |
| Zdroj: | Archives Internationales de Physiologie et de Biochimie. 88:137-146 |
| ISSN: | 0003-9799 |
| Popis: | A "bolus" dose (110 microgram) of the angiotesin II (A II)-blocker 1-Sar-8-Ala-A II (Saralasin, S) followed by its slow rate infusion (5 microgram/min/rat) for thirty min, was injected before and after the complete ganglionic blockade by pentolinium (P) in unanaesthetized unilaterally clipped renal hypertensive rats (the opposite kidney remained untouched). Pentolinium was also injected like a "bolus" dose (3 mg) followed by slow infusion (0.1 mg/min/rat) for thirty min. The observations were made until the fifth week after clipping the left renal artery. A consistent maximal hypotensive response was observed after the "bolus test" with both drugs. When S was the first drug injected, an inverse correlation was found between the percent decrease in arterial pressure (BP) by S and the percent decrease in BP by P (r = --0.83, P0.01, n = 8). Thus whenever a greater hypotensive effect was obtained by S, a smaller neural pressor component remained to be blocked by P. On the other hand, when P was the first drug injected a lesser A II pressor component remained to be blocked by S in the hypertensive rats. The results suggest that a considerable A II pressor effect in two-kidney renovascular hypertension is mediated via neurogenic mechanisms from the first week. A direct pressor vasoconstriction was found to be significant in cases with very high plasma-renin activity. |
| Databáze: | OpenAIRE |
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