Noninvasive Differentiation between Hepatic Steatosis and Steatohepatitis with MR Imaging Enhanced with USPIOs in Patients with Nonalcoholic Fatty Liver Disease: A Proof-of-Concept Study
| Autor: | Bram F. Coolen, Wouter H. Nijhof, Joanne Verheij, Loek P. Smits, Jaap Stoker, Jurgen H. Runge, Aart J. Nederveen, Ulrich Beuers, Maria D. Panno, Erik S.G. Stroes, Max Nieuwdorp |
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| Přispěvatelé: | Graduate School, Vascular Medicine, Biomedical Engineering and Physics, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Radiology and Nuclear Medicine, Pathology, ACS - Amsterdam Cardiovascular Sciences, Experimental Vascular Medicine, CCA -Cancer Center Amsterdam, Gastroenterology and Hepatology, Internal medicine, ICaR - Circulation and metabolism |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Nonalcoholic steatohepatitis Pathology medicine.medical_specialty Contrast Media digestive system 030218 nuclear medicine & medical imaging Diagnosis Differential 03 medical and health sciences 0302 clinical medicine Non-alcoholic Fatty Liver Disease Image Interpretation Computer-Assisted Nonalcoholic fatty liver disease medicine Humans Radiology Nuclear Medicine and imaging In patient Prospective Studies Magnetite Nanoparticles Aged medicine.diagnostic_test business.industry Dextrans Magnetic resonance imaging Middle Aged Image Enhancement medicine.disease Magnetic Resonance Imaging Mr imaging digestive system diseases Case-Control Studies Female 030211 gastroenterology & hepatology Steatosis Steatohepatitis Differential diagnosis business |
| Zdroj: | Radiology, 278(3), 782-791. Radiological Society of North America Inc. Radiology, 278(3), 782-91. Radiological Society of North America Inc. Smits, L P, Coolen, B F, Panno, M D, Runge, J H, Nijhof, W H, Verheij, J, Nieuwdorp, M, Stoker, J, Beuers, U H, Nederveen, A J & Stroes, E S 2016, ' Noninvasive Differentiation between Hepatic Steatosis and Steatohepatitis with MR Imaging Enhanced with USPIOs in Patients with Nonalcoholic Fatty Liver Disease : A Proof-of-Concept Study ', Radiology, vol. 278, no. 3, pp. 782-91 . https://doi.org/10.1148/radiol.2015150952 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiol.2015150952 |
| Popis: | Purpose: To (a) study the optimal timing and dosing for ultrasmall superparamagnetic iron oxide particle (USPIO)-enhanced magnetic resonance (MR) imaging of the liver in nonalcoholic fatty liver disease, (b) evaluate whether hepatic USPIO uptake is decreased in nonalcoholic steatohepatitis (NASH), and (c) study the diagnostic accuracy of USPIO-enhanced MR imaging to distinguish between NASH and simple steatosis. Materials and Methods: This prospective study was approved by the local institutional review board, and informed consent was obtained from all patients. Quantitative R2* MR imaging of the liver was performed at baseline and 72 hours after USPIO administration in patients with biopsy-proven NASH (n = 13), hepatic steatosis without NASH (n = 11), and healthy control subjects (n = 9). The hepatic USPIO uptake in the liver was quantified by the difference in R2* (Delta R2*) between the contrast material-enhanced images and baseline images. Between-group differences in mean Delta R2* were tested with the Student t test, and diagnostic accuracy was tested by calculating the area under the receiver operating characteristic curve. Results: Patients with NASH had a significantly lower Delta R2* 72 hours after USPIO administration when compared with patients who had simple steatosis and healthy control subjects (mean +/- standard deviation for patients with NASH, 37.0 sec(-1) +/- 16.1; patients with simple steatosis, 61.0 sec(-1) +/- 17.3; and healthy control subjects, 72.2 sec(-1) +/- 22.0; P =.006 for NASH vs simple steatosis; P |
| Databáze: | OpenAIRE |
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