Survey of Anti-human T-Cell Leukemia Virus Type I Antibody in Family Members of Patients with Adult T-Cell Leukemia
| Autor: | Kenichiro Kinoshita, Yasuaki Yamada, Shimeru Kamihira, Saburo Momita, Michito Ichimaru, Masao Tomonaga, Hisashi Soda, Shuichi Ikeda, Amagasaki T |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Leukemia T-Cell viruses T-cell leukemia Viral transmission Article Virus Sex Factors immune system diseases Adult T‐cell leukemia hemic and lymphatic diseases Internal medicine Female patient medicine Humans Family Aged Human T-lymphotropic virus 1 HTLV‐I biology business.industry Age Factors virus diseases Middle Aged medicine.disease Family study HTLV-I Antibodies Pedigree Human T cell leukemia virus Leukemia Oncology I antibody Immunology biology.protein population characteristics Female Viral disease Antibody business |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| Popis: | To evaluate the intrafamilial clustering of HTLV-I, we examined the sera or plasma of 296 healthy family members of patients with adult T-cell leukemia (ATL) for anti-HTLV-I antibodies. Of 296 subjects, 132 (44.6%) had anti-HTLV-I antibodies. Fifty-nine (41.0%) out of 144 males and 73 (48.0%) out of 152 females were seropositive. The positive rates of antibody to HTLV-I increased with age, especially between the 30-39 and the 40-49 age groups. Five out of 6 fathers, 3 out of 4 mothers, 31 (60.8%) out of 51 spouses, 40 (63.5%) out of 63 siblings and 46 (33.8%) out of 136 children of patients with ATL had anti-HTLV-I antibodies. Of 74 children with an ATL father, 14 (18.9%) were seropositive, while 32 (51.6%) out of 63 children with an ATL mother were seropositive. This difference was statistically significant (P less than 0.001). Of those children with an ATL father, 12 (26.1%) out of 46 whose mothers were HTLV-I carriers had antibodies to HTLV-I. In contrast, none of the 13 children whose mothers were not carriers were seropositive. These results supported the hypothesis that the mother-to-child transmission is one of the most important modes of HTLV-I transmission. In wives of male patients with ATL, the positive rate of antibody to HTLV-I was 65.6% (21/32), and in husbands of female patients, it was 52.6% (10/19). The high positive rate of antibody to HTLV-I not only in wives of male patients but also in husbands of female patients suggests that either HTLV-I is more frequently transmitted from wives to their husbands than we had originally expected, or that ATL may develop even in wives who acquire HTLV-I from their husbands after marriage. |
| Databáze: | OpenAIRE |
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