Ultrastructural studies of absorption of methoxychlor in the jejunal mucosa of the rat
| Autor: | Hideshige Imai, Frederick Coulston |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Male
Insecticides medicine.medical_specialty Clinical Biochemistry Golgi Apparatus Absorption (skin) Endoplasmic Reticulum Models Biological Basement Membrane Epithelium Intestinal absorption Pathology and Forensic Medicine symbols.namesake chemistry.chemical_compound Intestinal mucosa Internal medicine medicine Animals Intestinal Mucosa Molecular Biology Endoplasmic reticulum Biological Transport Methoxychlor Microtomy Golgi apparatus Mitochondria Rats Microscopy Electron Jejunum Endocrinology Intestinal Absorption chemistry symbols Ultrastructure Corn oil |
| Zdroj: | Experimental and Molecular Pathology. 8:135-158 |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/0014-4800(68)90012-9 |
| Popis: | Thirty-four male adult Wistar rats were given by gastric tubing either a single dose of 400 mg/kg or three consecutive daily doses of 1,600 mg/kg of methoxychlor dissolved in corn oil or suspended in aqueous polyvinylpyrrolidone. Controls were given equal amounts of vehicle alone. Specimens of the jejunal mucosa for light and electron microscopy were taken at 1 hour after the single dose or 24 hours after the last of three daily administrations. Material, probably derived from methoxychlor was identified as intra- and intercellular densities that were different from those derived from the vehicles. The route of absorption of all administered materials through the mucosa was largely similar except that the mixtures containing methoxychlor seemed to traverse to the intercellular spaces immediately after the passage through the luminal border in addition to the usual transport through the endoplasmic reticulum towards the Golgi apparatus. Furthermore, the absorption of methoxychlor was characterized by salient distention of vesicles and intercellular spaces that appeared nearly empty and larger than necessary to accommodate methoxychlor products. Overall cellular and organellar changes associated with absorption of methoxychlor at 1 hour and on the fourth day comprised a similar accentuation of asynchronous deterioration of organelles. Special reference was made to the occasional coexistence of intact and swollen mitochondria in the same columnar cells of the fasted controls and fed animals. |
| Databáze: | OpenAIRE |
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