Maternal viral infection during pregnancy elicits anti-social behavior in neonatal piglet offspring independent of postnatal microglial cell activation

Autor:	Jennifer L. Rytych, Adrienne M. Antonson, Marcus A. Lawson, Emily C. Radlowski, Rodney W. Johnson
Rok vydání:	2017
Předmět:	Lipopolysaccharides 0301 basic medicine Swine Offspring medicine.medical_treatment Genes MHC Class II Sus scrofa Immunology Porcine Reproductive and Respiratory Syndrome Spatial Learning Andrology 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Memory Pregnancy medicine Animals Porcine respiratory and reproductive syndrome virus Pregnancy Complications Infectious Social Behavior biology Microglia Endocrine and Autonomic Systems Antisocial Personality Disorder Macrophage Activation Porcine reproductive and respiratory syndrome virus biology.organism_classification medicine.disease Microglial cell activation 030104 developmental biology Cytokine medicine.anatomical_structure Prenatal Exposure Delayed Effects Cytokines Gestation Respiratory virus Female 030217 neurology & neurosurgery
Zdroj:	Brain, Behavior, and Immunity. 59:300-312
ISSN:	0889-1591
DOI:	10.1016/j.bbi.2016.09.019
Popis:	Maternal infection during pregnancy increases risk for neurodevelopmental disorders and reduced stress resilience in offspring, but the mechanisms are not fully understood. We hypothesized that piglets born from gilts infected with a respiratory virus during late gestation would exhibit aberrant microglia activity, cognitive deficits and reduced sociability. Pregnant gilts were inoculated with porcine reproductive and respiratory syndrome virus (PRRSV; 5×105 TCID50 of live PRRSV) or saline at gestational day 76. Gilts infected with PRRSV exhibited fever (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a36163e933ceb5f3c0013efb1c3df9f7 https://doi.org/10.1016/j.bbi.2016.09.019 Zobrazit plný text záznamu Full Text from ScienceDirect