Qualitative dimensions of exertional dyspnea in fibrotic interstitial lung disease
| Autor: | A. William Sheel, Satvir S. Dhillon, Sabrina S. Wilkie, Christopher J. Ryerson, Yannick Molgat-Seon, Reid A. Mitchell, Andrew H. Ramsook, Michele R. Schaeffer, Jordan A. Guenette |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Physiology Pulmonary Fibrosis Population Physical Exertion Exertional dyspnea 03 medical and health sciences FEV1/FVC ratio 0302 clinical medicine DLCO Internal medicine Pulmonary fibrosis medicine Tidal Volume Humans education Exercise Tidal volume Aged Aged 80 and over education.field_of_study business.industry General Neuroscience Interstitial lung disease respiratory system Middle Aged medicine.disease respiratory tract diseases Dyspnea 030228 respiratory system Breathing Cardiology Female business Lung Diseases Interstitial 030217 neurology & neurosurgery |
| Zdroj: | Respiratory physiologyneurobiology. 266 |
| ISSN: | 1878-1519 |
| Popis: | Unsatisfied inspiration is commonly reported during exercise by patients with interstitial lung disease (ILD). However, the physiological basis of perceived dyspnea quality in this population has not been evaluated. We examined the relationship between dyspnea quality and indices of ventilatory-mechanical limitations during exercise in patients with fibrotic ILD. Sixteen fibrotic ILD patients (12 male) with a median age of 64 years (range 49-81), FVC 71%-predicted (51-100), and DLCO 47%-predicted (27-77) performed incremental and constant work-rate cycle exercise tests to exhaustion. Ventilatory responses were recorded at rest, throughout exercise, and at peak exercise. Dyspnea quality was serially assessed using a 4-item list from which participants selected the phrase that best described their breathing compared to rest. Increased work/effort was the dominant descriptor of dyspnea throughout exercise, but with increased selection of unsatisfied inspiration following the inflection point of tidal volume relative to ventilation. Delaying or preventing ILD patients from reaching a critically reduced IRV may have implications for symptom management. |
| Databáze: | OpenAIRE |
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