Inter-observer variability between general pathologists and a specialist in breast pathology in the diagnosis of lobular neoplasia, columnar cell lesions, atypical ductal hyperplasia and ductal carcinoma in situ of the breast

Autor: Simone Souza Porto, Helenice Gobbi, Débora Balabram, Douglas Soltau Gomes
Rok vydání: 2014
Předmět:
Pathology
Biopsy
Lobular carcinoma
Atypical ductal hyperplasia
Breast cancer
Atypia
skin and connective tissue diseases
Referral and Consultation
Aged
80 and over
Observer Variation
Pathology
Clinical
medicine.diagnostic_test
Columnar cell lesions
General Medicine
Middle Aged
Hyperplasia
Female
Brazil
Specialization
Adult
medicine.medical_specialty
Histology
Adolescent
Breast Neoplasms
Agreement
Pathology and Forensic Medicine
Young Adult
Predictive Value of Tests
medicine
Carcinoma
Humans
Lobular neoplasia
Mammary Glands
Human
Aged
Retrospective Studies
business.industry
Research
Ductal carcinoma in situ
Inter-observer variability
Reproducibility of Results
Ductal carcinoma
medicine.disease
body regions
Carcinoma
Lobular
Carcinoma
Intraductal
Noninfiltrating
Cross-Sectional Studies
business
Lobular Neoplasia
Zdroj: Diagnostic Pathology
ISSN: 1746-1596
Popis: This study aimed to assess inter-observer variability between the original diagnostic reports and later review by a specialist in breast pathology considering lobular neoplasias (LN), columnar cell lesions (CCL), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) of the breast. A retrospective, observational, cross-sectional study was conducted. A total of 610 breast specimens that had been formally sent for consultation and/or second opinions to the Breast Pathology Laboratory of Federal University of Minas Gerais were analysed between January 2005 and December 2010. The inter-observer variability between the original report and later review was compared regarding the diagnoses of LN, CCL, ADH, and DCIS. Statistical analyses were conducted using the Kappa index. Weak correlations were observed for the diagnoses of columnar cell change (CCC; Kappa = 0.38), columnar cell hyperplasia (CCH; Kappa = 0.32), while a moderate agreement (Kappa = 0.47) was observed for the diagnoses of flat epithelial atypia (FEA). Good agreement was observed in the diagnoses of atypical lobular hyperplasia (ALH; Kappa = 0.62) and lobular carcinoma in situ (LCIS; Kappa = 0.66). However, poor agreement was observed for the diagnoses of pleomorphic LCIS (Kappa = 0.22). Moderate agreement was observed for the diagnoses of ADH (Kappa = 0.44), low-grade DCIS (Kappa = 0.47), intermediate-grade DCIS (Kappa = 0.45), and DCIS with microinvasion (Kappa = 0.56). Good agreement was observed between the diagnoses of high-grade DCIS (Kappa = 0.68). According to our data, the best diagnostic agreements were observed for high-grade DCIS, ALH, and LCIS. CCL without atypia and pleomorphic LCIS had the worst agreement indices. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1640072350119725 .
Databáze: OpenAIRE
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