Circulating leptin and adiponectin and their relation to glucose metabolism in children with Crohn’s disease and ulcerative colitis
| Autor: | Yannis Manios, Eleftheria Roma, Ioanna Panayotou, Giorgos Chouliaras, George P. Chrousos, Emilia Mantzou, Panagiota Pervanidou, Daphne Margoni |
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| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Leptin Male medicine.medical_specialty Adolescent Disease Carbohydrate metabolism Statistics Nonparametric Body Mass Index Crohn Disease Internal medicine medicine Humans Insulin Colitis Child Crohn's disease Greece Adiponectin business.industry digestive oral and skin physiology nutritional and metabolic diseases medicine.disease Ulcerative colitis digestive system diseases Cross-Sectional Studies Glucose Endocrinology Pediatrics Perinatology and Child Health Linear Models Colitis Ulcerative Female business Body mass index hormones hormone substitutes and hormone antagonists |
| Zdroj: | Pediatric Research. 74:420-426 |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Crohn's disease (CD) and ulcerative colitis (UC) result in metabolic consequences. We assessed circulating leptin and adiponectin concentrations and examined their relations to glucose metabolism in children with CD and UC.Circulating morning fasting concentrations of leptin, adiponectin, glucose, and insulin were measured in 32 children with CD and 18 children with UC. Insulin resistance (IR) and β-cell function were evaluated by the updated homeostatic model assessments (HOMA2-IR and HOMA2-B).Leptin was positively related to BMI z-scores overall and in the CD and the UC subgroups (P0.001). A negative correlation between leptin and disease activity was observed in the entire population (P = 0.034) and in the UC (P = 0.03) group. None of the assessed parameters was related to adiponectin. Fourteen percent of the participants were insulin resistant (15.6% in the CD group and 11.1% in the UC group), significantly more than expected (P0.001). Leptin was associated with HOMA2-IR (overall: r = 0.29, P = 0.045). Pathway analysis suggested that, overall, disease activity and BMI significantly affect leptin, which in turn is the only correlate of HOMA2-IR.Disease activity was significantly and inversely related to leptin in children with inflammatory bowel disease (IBD). A significant proportion of the patients had increased IR, which is positively related to circulating leptin. |
| Databáze: | OpenAIRE |
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