Antiviral Therapeutic Potential of Curcumin: An Update
| Autor: | Abolghasem Siyadatpanah, Ahdieh Izanloo, Marziyeh Zahani, Sahar Aleshikh, Mohammad Hassan Pouriayevali, Polrat Wilairatana, Hadi Razavi Nikoo, Henrique Douglas Melo Coutinho, Mehdi Ajorloo, Abdollah Ardebili |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Web of science
Pharmaceutical Science Organic chemistry Review Pharmacology Antiviral Agents Analytical Chemistry antiviral agent chemistry.chemical_compound human viruses X QD241-441 Drug Discovery Humans Medicine curcumin Physical and Theoretical Chemistry IC50 business.industry herbs chemistry Virus Diseases Chemistry (miscellaneous) Curcumin Molecular Medicine Viral disease business |
| Zdroj: | Molecules, Vol 26, Iss 6994, p 6994 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | The treatment of viral disease has become a medical challenge because of the increasing incidence and prevalence of human viral pathogens, as well as the lack of viable treatment alternatives, including plant-derived strategies. This review attempts to investigate the trends of research on in vitro antiviral effects of curcumin against different classes of human viral pathogens worldwide. Various electronic databases, including PubMed, Scopus, Web of Science, and Google Scholar were searched for published English articles evaluating the anti-viral activity of curcumin. Data were then extracted and analyzed. The forty-three studies (published from 1993 to 2020) that were identified contain data for 24 different viruses. The 50% cytotoxic concentration (CC50), 50% effective/inhibitory concentration (EC50/IC50), and stimulation index (SI) parameters showed that curcumin had antiviral activity against viruses causing diseases in humans. Data presented in this review highlight the potential antiviral applications of curcumin and open new avenues for further experiments on the clinical applications of curcumin and its derivatives. |
| Databáze: | OpenAIRE |
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