Sensitization to thiourea derivatives among Finnish patients with suspected contact dermatitis
| Autor: | Tapio Rantanen, Kaija Lammintausta, Jussi Liippo, Leena Ackermann, Arja Laukkanen, Taina Hasan |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Allergy medicine.medical_specialty Adolescent Dermatology Sports Equipment Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Latex Hypersensitivity medicine Humans Immunology and Allergy Dibutylthiourea 030212 general & internal medicine Allergic contact dermatitis Finland Sensitization Aged sports equipment Braces business.industry Thiourea Patch test Middle Aged Patch Tests medicine.disease Shoes 3. Good health medicine.anatomical_structure chemistry Dermatitis Allergic Contact Immunology Female Rubber business Contact dermatitis |
| Zdroj: | Contact Dermatitis. 63:37-41 |
| ISSN: | 1600-0536 0105-1873 |
| Popis: | Background: Thiourea derivatives in rubber products may induce contact sensitization and allergic contact dermatitis. Sensitization is most often from neoprene rubber, but the multitude of possible sensitizing products has remained poorly characterized. Objective: The aim of this study was to collect information on the occurrence of thiourea-related contact allergy and to show novel sources of sensitization. Patients and methods: A mixture of dibutyl-, diethyl-, and diphenylthiourea was included in patch test baseline series in five Finnish dermatology clinics during 2002–2007. In addition, an extended series of rubber chemicals was tested in patients with suspected rubber allergy. Sources of sensitization to thioureas were analysed in sensitized patients. Results: Thiourea mix yielded positive patch test reactions in 59 of 15 100 patients (0.39%); 33/59 patients were also tested with individual rubber chemicals. Diethylthiourea was positive in 24/33, diphenylthiourea in 5, and dibutylthiourea in 1 patient. The most common sources of sensitization included various neoprene-containing orthopaedic braces, sports equipment, and foot wear. Conclusions: The sources of sensitization to thiourea chemicals were detected in most cases. These sources comprise a heterogenous group of products extending from orthopaedic materials to sports equipment. |
| Databáze: | OpenAIRE |
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