Metabolomics as a tool to elucidate biochemical cold adaptation in insects

Autor: Hayward, Scott A.L., Colinet, H
Přispěvatelé: University of Birmingham [Birmingham], Ecosystèmes, biodiversité, évolution [Rennes] (ECOBIO), Université de Rennes (UR)-Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Observatoire des Sciences de l'Univers de Rennes (OSUR), Université de Rennes (UR)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut national des sciences de l'Univers (INSU - CNRS)-Université de Rennes 2 (UR2)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centre National de la Recherche Scientifique (CNRS), Funding: HC is supported by ANR Drothermal (ANR-20-CE02-0011-01). SALH is currently funded by NSFGEO-NERC grant (NE/T009446/1), NERC Treescapes Grant (NE/V021346/1)., ANR-20-CE02-0011,DroThermal,Qu'est-ce qui fait de Drosophila suzukii un envahisseur si efficace? Une analyse intégrative de son écologie thermique.(2020)
Rok vydání: 2023
Předmět:
Zdroj: Current Opinion in Insect Science
Current Opinion in Insect Science, 2023, 58, pp.101061. ⟨10.1016/j.cois.2023.101061⟩
ISSN: 2214-5745
DOI: 10.1016/j.cois.2023.101061
Popis: International audience; Metabolomics is an incredibly valuable tool in helping understand insect responses to cold. It not only characterizes how low temperature disrupts metabolic homeostasis, but also how it triggers fundamental adaptive responses, e.g. homeoviscous adaptation and cryoprotectant accumulation. This review outlines the advantages and disadvantages of different metabolomic technologies (NMR- vs. MS-based) and screening approaches (targeted vs. untargeted). We emphasize the importance of time series and tissue-specific data, as well as the challenges of disentangling insect vs. microbiome responses. In addition, we set out the need to move beyond simple correlations between metabolite abundance and tolerance phenotypes by undertaking functional assessments, e.g. using dietary supplementation or injections. We highlight studies at the vanguard of employing these approaches, and where key knowledge gaps remain.
Databáze: OpenAIRE
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