Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle?
| Autor: | Liabeuf, Sophie, Pepin, Marion, Franssen, Casper, Viggiano, Davide, Carriazo, Sol, Gansevoort, Ron, Gesualdo, Loreto, Hafez, Gaye, Malyszko, Jolanta, Mayer, Christopher, Nitsch, Dorothea, Ortiz, Alberto, Pešić, Vesna, Wiecek, Andrzej, Massy, Ziad, Capasso, Giovambattista, Andrade, Alexandre, Bachmann, Maie, Bumblyte, Inga, Covic, Adrian Constantin, Delgado, Pilar, Endlich, Nicole, Engvig, Andreas, Fouque, Denis, Frische, Sebastian, Garneata, Liliana, Giannakou, Konstantinos, Goumenos, Dimitrios, Kartal, Ayşe Tuğba, Mani, Laila-Yasmin, Marti, Hans-Peter, Nielsen, Rikke, Rroji, Merita, Sakkas, Giorgos, Spasovski, Goce, Stevens, Kate, Vazelov, Evgueniy, Zacharia, Lefteris, Ferreira, Ana Carina, Hoorn, Ewout, Figurek, Andreja, Unwin, Robert, Wagner, Carsten, Wanner, Christoph, BRUCHFELD, Annette, Fridolin, Ivo, Romeo, Maria José Soler, Barbieri, Michelangela, Batinić, Bojan, Carrasco, Laura, Martino, Gianvito, Raso, Francesco Mattace, Nistor, Ionut, Paolisso, Giuseppe, Rastenytė, Daiva, Stefan, Gabriel, Tedeschi, Gioacchino, Bikbov, Boris, Endlich, Karl Hans, Godefroy, Olivier, Chillon, Jean-Marc, Kossioni, Anastassia, Kurganaite, Justina, Perico, Norberto, Remuzzi, Giuseppe, Grodzicki, Tomasz, Trepiccione, Francesco, Zoccali, Carmine, Arici, Mustafa, Blankestijn, Peter, Eckardt, Kai-Uwe, Fliser, Danilo, Jiménez, Eugenio Gutiérrez, Konig, Maximilian, Rychlik, Ivan, Deleidi, Michela, REUSZ, George |
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| Přispěvatelé: | Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Hôpital Ambroise Paré [AP-HP], Groningen University Medical Centre, Department of Nephrology [Groningue, Pays-Bas], University Medical Center Groningen [Groningen] (UMCG), CeRTA, Liabeuf, S., Pepin, M., Franssen, C. F. M., Viggiano, D., Carriazo, S., Gansevoort, R. T., Gesualdo, L., Hafez, G., Malyszko, J., Mayer, C., Nitsch, D., Ortiz, A., Pesic, V., Wiecek, A., Massy, Z. A. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
CLINICAL-OUTCOMES HEMODIALYSIS Movement disorders 030232 urology & nephrology RENAL DYSFUNCTION URIC-ACID Review 03 medical and health sciences 0302 clinical medicine PARKINSONS-DISEASE Diabetes mellitus Internal medicine Epidemiology medicine CKD INDOXYL SULFATE AcademicSubjects/MED00340 Stroke Depression (differential diagnoses) RISK Transplantation Kidney COMPLICATIONS business.industry cardiovascular medicine.disease COGNITIVE FUNCTION indoxyl sulphate stroke 3. Good health medicine.anatomical_structure Clinical research Nephrology [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie medicine.symptom business 030217 neurology & neurosurgery Kidney disease uraemic toxins |
| Zdroj: | Nephrology Dialysis Transplantation Nephrology Dialysis Transplantation, Oxford University Press (OUP), 2021, ⟨10.1093/ndt/gfab223⟩ Liabeuf, Sophie; Pepin, Marion; Franssen, Casper F M; Viggiano, Davide; Carriazo, Sol; Gansevoort, Ron T; Gesualdo, Loreto; Hafez, Gaye; Malyszko, Jolanta; Mayer, Christopher; Nitsch, Dorothea; Ortiz, Alberto; Pešić, Vesna; Wiecek, Andrzej; Massy, Ziad A (2021). Chronic kidney disease and neurological disorders: are uraemic toxins the missing piece of the puzzle? Nephrology, dialysis, transplantation, 37(Supplement_2), ii33-ii44. Oxford University Press 10.1093/ndt/gfab223 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/gfab223⟩ |
| Popis: | Chronic kidney disease (CKD) perturbs the crosstalk with others organs, with the interaction between the kidneys and the heart having been studied most intensively. However, a growing body of data indicates that there is an association between kidney dysfunction and disorders of the central nervous system. In epidemiological studies, CKD is associated with a high prevalence of neurological complications, such as cerebrovascular disorders, movement disorders, cognitive impairment and depression. Along with traditional cardiovascular risk factors (such as diabetes, inflammation, hypertension and dyslipidaemia), non-traditional risk factors related to kidney damage (such as uraemic toxins) may predispose patients with CKD to neurological disorders. There is increasing evidence to show that uraemic toxins, for example indoxyl sulphate, have a neurotoxic effect. A better understanding of factors responsible for the elevated prevalence of neurological disorders among patients with CKD might facilitate the development of novel treatments. Here, we review (i) the potential clinical impact of CKD on cerebrovascular and neurological complications, (ii) the mechanisms underlying the uraemic toxins’ putative action (based on pre-clinical and clinical research) and (iii) the potential impact of these findings on patient care. Graphical Abstract Graphical Abstract |
| Databáze: | OpenAIRE |
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