Circadian clocks and feeding time regulate the oscillations and levels of hepatic triglycerides
| Autor: | Gad Asher, Xianlin Han, Liat Rousso-Noori, Judith Kraut-Cohen, Miao Wang, Yaarit Adamovich, Marina Golik, Ziv Zwighaft, Adi Neufeld-Cohen |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Physiology Circadian clock Biology Real-Time Polymerase Chain Reaction Models Biological Article chemistry.chemical_compound Mice Internal medicine Circadian Clocks medicine Triglyceride metabolism Animals Circadian rhythm Molecular Biology Cholesterol homeostasis Triglycerides 2. Zero hunger chemistry.chemical_classification Triglyceride Fatty liver Cell Biology medicine.disease Endocrinology Enzyme chemistry Liver |
| Zdroj: | Cell metabolism. 19(2) |
| ISSN: | 1932-7420 |
| Popis: | SummaryCircadian clocks play a major role in orchestrating daily physiology, and their disruption can evoke metabolic diseases such as fatty liver and obesity. To study the role of circadian clocks in lipid homeostasis, we performed an extensive lipidomic analysis of liver tissues from wild-type and clock-disrupted mice either fed ad libitum or night fed. To our surprise, a similar fraction of lipids (∼17%) oscillated in both mouse strains, most notably triglycerides, but with completely different phases. Moreover, several master lipid regulators (e.g., PPARα) and enzymes involved in triglyceride metabolism retained their circadian expression in clock-disrupted mice. Nighttime restricted feeding shifted the phase of triglyceride accumulation and resulted in ∼50% decrease in hepatic triglyceride levels in wild-type mice. Our findings suggest that circadian clocks and feeding time dictate the phase and levels of hepatic triglyceride accumulation; however, oscillations in triglycerides can persist in the absence of a functional clock. |
| Databáze: | OpenAIRE |
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