Radiotherapy for Pediatric Brain Stem Glioma
| Autor: | Tatsuya Kondo, Isao Hayakawa, Kazuhiro Nomura, Shigeru Genka, Nobuyuki Shitara, Kintomo Takakura, Tomio Tsuchida, Tokuro Fuchinoue, Tetsuo Hibi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Adolescent Biopsy medicine.medical_treatment Autopsy Glioma medicine Humans Child Neoplasm Staging Retrospective Studies Brain Neoplasms business.industry Radiation dose Infant Radiotherapy Dosage medicine.disease Magnetic Resonance Imaging Survival Analysis Survival Rate Radiation therapy El Niño Child Preschool Radiological weapon Multivariate Analysis Female Surgery Neurology (clinical) Cranial Irradiation Tomography X-Ray Computed Complication business Nuclear medicine Brain Stem Calcification |
| Zdroj: | Neurosurgery. 31:643-651 |
| ISSN: | 0148-396X |
| Popis: | An analysis of 39 patients under 20 years of age with brain stem glioma treated with radiotherapy between 1977 and 1991 was undertaken. Twenty-eight (71.2%) of the patients responded well to initial radiotherapy, and 11 (28.8%) responded poorly. Median survival for the total patient population was 10 months. Response rates and median survivals were influenced by radiation dose: 45.5% and 9 months at doses less than 4499 cGy (n = 11), 83.3% and 13 months at doses between 4500 and 5499 cGy (n = 12), 66.7% and 11.5 months at doses between 5500 and 6499 cGy (n = 9), and 100% and 10 months at doses more than 6500 cGy (n = 7). Multivariate analysis revealed the response to initial radiotherapy was the only predictor of survival with radiation doses up to 6499 cGy. Four of the patients who responded well demonstrated radiological and/or histological calcification within or around the tumor at the time of clinical deterioration. Radiation injury was confirmed in two autopsy cases. The possibility that intratumoral radiation injury causes clinical deterioration is suggested. |
| Databáze: | OpenAIRE |
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