Supplementary Figure 1 from Immune Response Is an Important Aspect of the Antitumor Effect Produced by a CD40L-Encoding Oncolytic Adenovirus

Autor: Akseli Hemminki, Sari Pesonen, Aristides G. Eliopoulos, Angelica S.I. Loskog, Anna Kanerva, Suvi Parviainen, Simona Bramante, Saila K. Pesonen, Matteo Ugolini, Sophie Escutenaire, Mari L.M. Hirvinen, Vincenzo Cerullo, Iulia Diaconu
Rok vydání: 2023
Popis: PDF file - 881K, (A) Oncolytic potency of Ad5/3-hTERT-E1A-hCD40L and (B) Ad5/3-hTERT-E1A on EJ (CD40+) and A549 (CD40-). Cell lines were infected with Ad5/3Luc1, Ad5/3-hTERT-E1A, Ad5/3-hTERT-E1A-hCD40L and Ad5/3-CMV-hCD40L and cell viability was measured by MTS assay The assay was stopped 7 days after infection and the data was plotted to compare efficacy on CD40+ versus CD40- cells; Ad5/3-hTERT-E1A-hCD40L was more effective than the positive control on the former while the opposite was true for the latter. . VP=viral particles. ***, P
Databáze: OpenAIRE