Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage
| Autor: | Hendriksen, Rene S., Munk, Patrick, Njage, Patrick, van Bunnik, Bram, McNally, Luke, Lukjancenko, Oksana, Röder, Timo, Nieuwenhuijse, David, Pedersen, Susanne Karlsmose, Kjeldgaard, Jette, Kaas, Rolf S., Clausen, Philip Thomas Lanken Conradsen, Vogt, Josef Korbinian, Leekitcharoenphon, Pimlapas, van de Schans, Milou G.M., Zuidema, Tina, de Roda Husman, Ana Maria, Rasmussen, Simon, Petersen, Bent, Bego, Artan, Rees, Catherine, Cassar, Susan, Coventry, Kris, Collignon, Peter, Allerberger, Franz, Rahube, Teddie O., Oliveira, Guilherme, Ivanov, Ivan, Vuthy, Yith, Sopheak, Thet, Yost, Christopher K., Ke, Changwen, Zheng, Huanying, Baisheng, Li, Jiao, Xiaoyang, Donado-Godoy, Pilar, Coulibaly, Kalpy Julien, Jergović, Matijana, Hrenovic, Jasna, Karpíšková, Renáta, Villacis, Jose Eduardo, Legesse, Mengistu, Eguale, Tadesse, Heikinheimo, Annamari, Malania, Lile, Nitsche, Andreas, Brinkmann, Annika, Saba, Courage Kosi Setsoafia, Kocsis, Bela, Solymosi, Norbert, Thorsteinsdottir, Thorunn R., Hatha, Abdulla Mohamed, Alebouyeh, Masoud, Morris, Dearbhaile, Cormican, Martin, O’Connor, Louise, Moran-Gilad, Jacob, Alba, Patricia, Battisti, Antonio, Shakenova, Zeinegul, Kiiyukia, Ciira, Ng’eno, Eric, Raka, Lul, Avsejenko, Jeļena, Bērziņš, Aivars, Bartkevics, Vadims, Penny, Christian, Rajandas, Heraa, Parimannan, Sivachandran, Haber, Malcolm Vella, Pal, Pushkar, Jeunen, Gert Jan, Gemmell, Neil, Fashae, Kayode, Holmstad, Rune, Hasan, Rumina, Shakoor, Sadia, Rojas, Maria Luz Zamudio, Wasyl, Dariusz, Bosevska, Golubinka, Kochubovski, Mihail, Radu, Cojocaru, Gassama, Amy, Radosavljevic, Vladimir, Wuertz, Stefan, Zuniga-Montanez, Rogelio, Tay, Moon Y.F., Gavačová, Dagmar, Pastuchova, Katarina, Truska, Peter, Trkov, Marija, Esterhuyse, Kerneels, Keddy, Karen, Cerdà-Cuéllar, Marta, Pathirage, Sujatha, Norrgren, Leif, Örn, Stefan, Larsson, D. G.Joakim, Heijden, Tanja Van der, Kumburu, Happiness Houka, Sanneh, Bakary, Bidjada, Pawou, Njanpop-Lafourcade, Berthe Marie, Nikiema-Pessinaba, Somtinda Christelle, Levent, Belkis, Meschke, John Scott, Beck, Nicola Koren, Van, Chinh Dang, Tran, Doan Minh Nguyen, Kwenda, Geoffrey, Tabo, Djim adjim, Wester, Astrid Louise, Cuadros-Orellana, Sara, Amid, Clara, Cochrane, Guy, Sicheritz-Ponten, Thomas, Schmitt, Heike, Alvarez, Jorge Raul Matheu, Aidara-Kane, Awa, Pamp, Sünje J., Lund, Ole, Hald, Tine, Woolhouse, Mark, Koopmans, Marion P., Vigre, Håkan, Petersen, Thomas Nordahl, Aarestrup, Frank M., Sub RIVM, dIRAS RA-I&I RA, One Health Microbieel, dIRAS RA-I&I I&I |
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| Přispěvatelé: | University of Helsinki, Food Hygiene and Environmental Health, Producció Animal, Sanitat Animal, Tilraunastöð í meinafræði að Keldum (HÍ), Institute for Experimental Pathology, Keldur (UI), Heilbrigðisvísindasvið (HÍ), School of Health Sciences (UI), Háskóli Íslands, University of Iceland, Food Hygiene and Environmental Health, Helsinki One Health (HOH), Zoonotic Antimicrobial Resistance, Virology |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Water microbiology global surveillance Sanitation Kwantitatieve Veterinaire Epidemiologie Drug Resistance General Physics and Astronomy Sewage 02 engineering and technology Drug resistance Antimicrobial resistance 413 Veterinary science BU Veterinary Drugs Abundance (ecology) Drug Resistance Multiple Bacterial Genamengi AMR lcsh:Science resistome Ónæmisfræði Multidisciplinary Population Health 021001 nanoscience & nanotechnology 3. Good health Europe machine learning Geography Epidemiological Monitoring 0210 nano-technology Asia Science Microbial Consortia Oceania Article General Biochemistry Genetics and Molecular Biology BU Dierbehandelingsmiddelen 03 medical and health sciences Antibiotic resistance SDG 3 - Good Health and Well-being Environmental health Erfðafræði Life Science Humans ddc:610 wastewater Ecological epidemiology Bacteria business.industry Quantitative Veterinary Epidemiology prediction General Chemistry South America Resistome 030104 developmental biology Genes Socioeconomic Factors 416 Food Science Genes Bacterial Metagenomics ENVIRONMENTAL SURVEILLANCE Africa North America Metagenome UPDATE lcsh:Q business 610 Medizin und Gesundheit |
| Zdroj: | Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019) Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Nature Communications 10 (2019) 1 Hendriksen, R S, Munk, P, Njage, P M K, van Bunnik, B, McNally, L, Lukjancenko, O, Röder, T, Nieuwenhuijse, D, Karlsmose Pedersen, S, Kjeldgaard, J S, Kaas, R S, Clausen, P T L C, Vogt, J K, Leekitcharoenphon, P, van de Schans, M G M, Zuidema, T, de Roda Husman, A M, Rasmussen, S, Petersen, B, Global, S S P C, Amid, C, Cochrane, G, Sicheritz-Pontén, T, Schmitt, H, Alvarez, J R M, Aidara-Kane, A, Pamp, S J, Lund, O, Hald, T, Woolhouse, M, Koopmans, M P, Vigre, H, Petersen, T N & Aarestrup, F M 2019, ' Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage ', Nature Communications, vol. 10, 1124 . https://doi.org/10.1038/s41467-019-08853-3 IRTA Pubpro. Open Digital Archive Institut de Recerca i Tecnologia Agroalimentàries (IRTA) Hendriksen, R S, Munk, P, Njage, P, van Bunnik, B, McNally, L, Lukjancenko, O, Röder, T, Nieuwenhuijse, D, Pedersen, S K, Kjeldgaard, J, Kaas, R S, Clausen, P T L C, Vogt, J K, Leekitcharoenphon, P, van de Schans, M G M, Zuidema, T, de Roda Husman, A M, Rasmussen, S, Petersen, B, Amid, C, Cochrane, G, Sicheritz-Ponten, T, Schmitt, H, Alvarez, J R M, Aidara-Kane, A, Pamp, S J, Lund, O, Hald, T, Woolhouse, M, Koopmans, M P, Vigre, H & Petersen, T N & Aarestrup, F M 2019, ' Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage ', Nature Communications, vol. 10, 1124 . https://doi.org/10.1038/s41467-019-08853-3 Nature Communications, 10(1) Nature Communications Nature Communications, 10:1124. Nature Publishing Group Nature Communications, 10(1124). Nature Publishing Group |
| ISSN: | 2041-1723 |
| Popis: | Publisher's version (útgefin grein) Antimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR. We are grateful to Hanne Nørgaard Nielsen, Christina Aaby Svendsen, Jacob Dyring Jensen, Birthe S. Rosenqvist Lund, Kate Vina Vibefeldt, Inge Marianne Hansen, Gunhild Larsen, Hanne Mordhorst, and Carsten Bidstrup for technical assistance. We also thank Jeffrey Edward Skiby for internal review. This study has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement no. 643476 (COMPARE), the World Health Organization, The Villum Foundation (VKR023052), and The Novo Nordisk Foundation (NNF16OC0021856: Global Surveillance of Antimicrobial Resistance). |
| Databáze: | OpenAIRE |
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