Stereotactic Radiosurgery as Part of Multimodal Treatment in a Bulky Leptomeningeal Recurrence of Breast Cancer
| Autor: | Eric Burton, M.H. Bertke, Joseph N Shaughnessy |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment stereotactic radiosurgery Neurosurgery Disease Radiosurgery 03 medical and health sciences 0302 clinical medicine Breast cancer breast cancer medicine Multimodal treatment reirradiation leptomeningeal business.industry General Engineering medicine.disease Response to treatment Disease control Surgery intrathecal chemotherapy Oncology 030220 oncology & carcinogenesis Radiation Oncology Radiology Intrathecal chemotherapy Whole brain radiation therapy business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Breast cancer metastatic to the brain and/or leptomeningeal spread of disease is a frequently encountered clinical situation, especially given the extended course of disease in these patients. Systemic therapies can often effectively prolong extracranial disease control, making effective strategies to control central nervous system-based disease even more critical. We present a case of bulky leptomeningeal relapse of breast cancer in the setting of prior whole brain radiation therapy. In order to treat the patient's bulky disease and leptomeningeal spread while avoiding the potential toxicities of repeat whole brain radiation, the patient was treated with frameless stereotactic radiosurgery and intrathecal chemotherapy. This is the first report of this treatment approach for leptomeningeal relapse of breast cancer. The patient had an excellent response to treatment and durable intracranial control. |
| Databáze: | OpenAIRE |
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