Interplay of Personal, Pet, and Environmental Colonization in Households Affected by Community-Associated Methicillin-Resistant Staphylococcus aureus
| Autor: | Mary G. Boyle, Andrey Rzhetsky, Ryley M. Thompson, Carol E. Muenks, Carey-Ann D. Burnham, Sarah Gehlert, Melanie L. Sullivan, Stephanie A. Fritz, Juliane Bubeck Wardenburg, Ryan L. Mork, John J. Morelli, Jessica R. Merlo, Matt G. McKenzie, Patrick G. Hogan |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Molecular epidemiology business.industry MRSA colonization Transmission (medicine) 030106 microbiology biochemical phenomena metabolism and nutrition medicine.disease_cause bacterial infections and mycoses Methicillin-resistant Staphylococcus aureus Article Community associated 03 medical and health sciences 0302 clinical medicine Infectious Diseases Staphylococcus aureus Environmental health medicine Colonization 030212 general & internal medicine business Index case |
| Popis: | Objective We sought to determine the prevalence, molecular epidemiology, and factors associated with Staphylococcus aureus environmental surface and pet colonization in households of children with community-associated methicillin-resistant S. aureus (CA–MRSA) infection. Methods Between 2012 and 2015, 150 children with CA–MRSA infections and their household contacts and pets were enrolled in this cross-sectional study in metropolitan Saint Louis, MO. Cultures to detect S. aureus were collected from 3 anatomic sites of household members, 2 dog/cat sites, and 21 environmental surfaces in each household. Molecular epidemiology of S. aureus isolates was determined via repetitive-sequence PCR. Generalized linear models were developed to identify factors associated with S. aureus/MRSA household contamination. Results MRSA was recovered from environmental surfaces in 69 (46%) households (median 2 surfaces [range 1–18]). The enrollment infecting strain type was the most common strain recovered from the environment in most (64%) households. In generalized linear models, factors associated with a higher proportion of MRSA-contaminated environmental surfaces were household member MRSA colonization burden, MRSA as the dominant S. aureus strain colonizing household members, more strain types per household member, index case African–American race, and renting (vs. owning) the home. Of 132 pets, 14% were colonized with MRSA. Pets whose primary caretaker was MRSA-colonized were more likely to be MRSA-colonized than pets whose primary caretaker was not MRSA-colonized (50% vs. 4%, p Conclusions Household environments and pet dogs and cats serve as reservoirs of MRSA. Household member MRSA colonization burden predicts environmental MRSA contamination. Longitudinal studies will inform the directionality of household transmission. |
| Databáze: | OpenAIRE |
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