Oscillations of plasma K+ and insulin during K+ infusion in awake anephric dogs
| Autor: | R. H. Sterns |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Male
medicine.medical_specialty Pentobarbital Physiology Feedback control medicine.medical_treatment Nephrectomy Dogs Internal medicine medicine Animals Insulin Infusions Parenteral Wakefulness Insulin secretion business.industry Pathophysiology Kinetics Somatostatin Endocrinology Serum potassium Potassium Female Pentobarbital anesthesia business medicine.drug |
| Zdroj: | American Journal of Physiology-Renal Physiology. 243:F44-F52 |
| ISSN: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.1982.243.1.f44 |
| Popis: | Changes in plasma potassium ([K+]p) and insulin levels were monitored during K+ infusion in awake and anesthetized nephrectomized, splenectomized dogs. In dogs studied while anesthetized with pentobarbital, the increase in [K+]p was linear, reflecting a nearly constant rate of cellular uptake of the infused K+. In contrast, in dogs studied 18 h after nephrectomy while awake, [K+]p oscillated during infusion, reflecting an inconstant rate of cellular K+ uptake. Although these oscillations in [K+]p were associated with parallel oscillations in plasma insulin levels (suggesting the possibility of a physiological feedback control loop involving K+ and insulin), when the oscillations in insulin levels were blunted by somatostatin infusion or abolished by pancreatectomy plus insulin replacement, oscillations in [K+]p persisted and the average rate of cellular K+ uptake was not diminished. The observed oscillations of [K+]p during K+ infusion suggest the possibility of regulatory control of cellular K+ uptake within the pathophysiologic range of [K+]p. The putative control system is independent of and quantitatively more important than K+-induced insulin secretion and is obscured by pentobarbital anesthesia. |
| Databáze: | OpenAIRE |
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