The Most Common Functional Groups in Bioactive Molecules and How Their Popularity Has Evolved over Time
| Autor: | Jeffrey Mckenna, Peter Ertl, Eva Altmann |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Molecular Structure Drug discovery Chemistry Bioactive molecules Chemistry Pharmaceutical Computational biology Ligands 01 natural sciences Popularity 0104 chemical sciences Small Molecule Libraries 010404 medicinal & biomolecular chemistry 03 medical and health sciences Pharmaceutical Preparations Drug Design Drug Discovery Molecular Medicine 030304 developmental biology |
| Zdroj: | Journal of medicinal chemistry. 63(15) |
| ISSN: | 1520-4804 |
| Popis: | The concept of functional groups (FGs), sets of connected atoms that can determine the intrinsic reactivity of the parent molecule and in part are responsible for the overall properties of the molecule, form a foundation within modern medicinal chemistry. In this Article, we analyze the occurrence of various FGs in molecules described in the medicinal chemistry literature over the last 40 years and show how their development and utilization over time has varied. The popularity of various FGs has not evolved randomly, but instead, clear patterns of use are evident. Various factors influencing these patterns, including the introduction of new synthetic methods, novel techniques, and strategies applied in drug discovery and the better knowledge of molecular properties affecting the success of candidate development, are discussed. |
| Databáze: | OpenAIRE |
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