Diabetic keratopathy: Insights and challenges
| Autor: | Dimitrios Karamichos, Kamran M. Riaz, Amy Whelchel, Shrestha Priyadarsini, Sarah E. Nicholas, Rabab Sharif |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Visual acuity genetic structures Article Corneal Diseases Cornea 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Ophthalmology Superficial punctate keratopathy Diabetes Mellitus medicine Humans Metabolic disease business.industry Regeneration (biology) medicine.disease eye diseases medicine.anatomical_structure Decreased corneal sensitivity 030221 ophthalmology & optometry Research studies medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Surv Ophthalmol |
| ISSN: | 0039-6257 |
| DOI: | 10.1016/j.survophthal.2020.02.005 |
| Popis: | Ocular complications from diabetes mellitus are common. Diabetic keratopathy, the most frequent clinical condition affecting the human cornea, is a potentially sight-threatening condition caused mostly by epithelial disturbances that are of clinical and research attention because of their severity. Diabetic keratopathy exhibits several clinical manifestations, including persistent corneal epithelial erosion, superficial punctate keratopathy, delayed epithelial regeneration, and decreased corneal sensitivity, that may lead to compromised visual acuity or permanent vision loss. The limited amount of clinical studies makes it difficult to fully understand the pathobiology of diabetic keratopathy. Effective therapeutic approaches are elusive. We summarize the clinical manifestations of diabetic keratopathy and discuss available treatments and up-to-date research studies in an attempt to provide a thorough overview of the disorder. |
| Databáze: | OpenAIRE |
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