Efficacy of emodepside plus praziquantel tablets (Profender tablets for dogs) against mature and immature cestode infections in dogs
| Autor: | Manuela Schnyder, Klemens Krieger, Annette Schimmel, Peter Deplazes, Iris Schroeder, Dawid J. Kok, Gertraut Altreuther |
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| Přispěvatelé: | University of Zurich, Altreuther, G |
| Rok vydání: | 2009 |
| Předmět: |
10078 Institute of Parasitology
1109 Insect Science 3400 General Veterinary Cestoda 2405 Parasitology Administration Oral 610 Medicine & health Pharmacology Praziquantel Placebos Feces Dogs Double-Blind Method 600 Technology Depsipeptides parasitic diseases medicine Helminths Animals Dog Diseases Echinococcus granulosus Dipylidium caninum Parasite Egg Count Anthelmintics General Veterinary biology 2725 Infectious Diseases General Medicine biology.organism_classification medicine.disease Cestode Infections Echinococcosis Infectious Diseases Treatment Outcome Insect Science Immunology 570 Life sciences Taenia Parasitology Emodepside medicine.drug Tablets |
| Zdroj: | Parasitology research. 105 |
| ISSN: | 1432-1955 |
| Popis: | The efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender tablets for dogs) against intestinal cestodes was investigated in four randomised, blinded placebo-controlled dose confirmation studies in dogs experimentally infected with Echinococcus granulosus or E. multilocularis and in dogs naturally infected with Dipylidium caninum or Taenia spp. The tablets were used at the minimum recommended dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. The studies demonstrated 100% efficacy against mature and immature E. granulosus and E. multilocularis and mature Taenia spp. and D. caninum. Additionally, one of the studies demonstrated non-interference of emodepside with the efficacy of praziquantel against D. caninum. No side effects of the treatment were observed. It is concluded that emodepside plus praziquantel tablets are safe and effective against mature and immature stages of E. granulosus and E. multilocularis and mature stages of Taenia spp. and D. caninum. |
| Databáze: | OpenAIRE |
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