Neurotoxicity of Acrylamide in Exposed Workers
| Autor: | Mariano Malaguarnera, Giulia Malaguarnera, Luisa Vinciguerra, Valentina Puglisi, Manuela Pennisi, Marco Vacante |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
musculoskeletal diseases
Neurotoxicity Syndrome Pathology medicine.medical_specialty Ataxia Health Toxicology and Mutagenesis Central nervous system lcsh:Medicine Bioinformatics Risk Assessment Article chemistry.chemical_compound Occupational Exposure neurotoxicity medicine Animals Humans skin and connective tissue diseases Acrylamide Mechanism (biology) business.industry lcsh:R Public Health Environmental and Occupational Health Neurotoxicity Muscle weakness medicine.disease Chemical used medicine.anatomical_structure chemistry workers neuropathy Neurotoxicity Syndromes medicine.symptom acrylamide business |
| Zdroj: | International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health; Volume 10; Issue 9; Pages: 3843-3854 International Journal of Environmental Research and Public Health, Vol 10, Iss 9, Pp 3843-3854 (2013) |
| ISSN: | 1660-4601 |
| Popis: | Acrylamide (ACR) is a water-soluble chemical used in different industrial and laboratory processes. ACR monomer is neurotoxic in humans and laboratory animals. Subchronic exposure to this chemical causes neuropathies, hands and feet numbness, gait abnormalities, muscle weakness, ataxia, skin and in some cases, cerebellar alterations. ACR neurotoxicity involves mostly the peripheral but also the central nervous system, because of damage to the nerve terminal through membrane fusion mechanisms and tubulovescicular alterations. Nevertheless, the exact action mechanism is not completely elucidated. In this paper we have reviewed the current literature on its neurotoxicity connected to work-related ACR exposure. We have analyzed not only the different pathogenetic hypotheses focusing on possible neuropathological targets, but also the critical behavior of ACR poisoning. In addition we have evaluated the ACR-exposed workers case studies. Despite all the amount of work which have being carried out on this topic more studies are necessary to fully understand the pathogenetic mechanisms, in order to propose suitable therapies. |
| Databáze: | OpenAIRE |
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