Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain

Autor: Sylvie Moritz-Gasser, Hugues Duffau, Guillaume Herbet, Matthew C. Tate, Stefano Merler, Silvio Sarubbo, Alessandro De Benedictis
Přispěvatelé: Division of Neurosurgery, Structural and Functional Connectivity Lab Project, Azienda Provinciale per i Servizi Sanitari (APSS), Feinberg School of Medicine, Northwestern University [Evanston], Bambino Gesù Children’s Hospital [Rome, Italy], NeuroInformatics Laboratory of Bruno Kessler Foundation (NILab), Università degli Studi di Trento (UNITN), Neurochirurgie [Hôpital Gui de Chauliac], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier], Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Salvy-Córdoba, Nathalie, Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM)
Rok vydání: 2019
Předmět:
[SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery
Computer science
[INFO.INFO-IM] Computer Science [cs]/Medical Imaging
Brain mapping
Neurosurgical Procedures
MESH: Magnetic Resonance Imaging
0302 clinical medicine
Neural Pathways
MESH: Brain Mapping
Cerebral Cortex
Brain Mapping
medicine.diagnostic_test
05 social sciences
MESH: Electric Stimulation
Cognition
Neuropsychological test
Human brain
Magnetic Resonance Imaging
White Matter
medicine.anatomical_structure
Neurology
Preoperative Period
Nerve tract
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Neuropsychological testing
Atlas
Adult
Cognitive Neuroscience
MESH: Atlases as Topic
Direct electrical stimulation
Subcortical
MESH: Preoperative Period
[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery
050105 experimental psychology
Article
lcsh:RC321-571
White matter
03 medical and health sciences
Atlases as Topic
Neuroimaging
medicine
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
0501 psychology and cognitive sciences
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
MESH: Humans
MESH: Neural Pathways
MESH: Adult
MESH: Neurosurgical Procedures
Neurophysiology
MESH: Cerebral Cortex
Electric Stimulation
Brain functions
MESH: White Matter
Neuroscience
030217 neurology & neurosurgery
Zdroj: Neuroimage
NeuroImage
NeuroImage, Elsevier, 2020, 205, pp.116237. ⟨10.1016/j.neuroimage.2019.116237⟩
NeuroImage, Vol 205, Iss, Pp 116237-(2020)
ISSN: 1095-9572
1053-8119
DOI: 10.1016/j.neuroimage.2019.116237⟩
Popis: Objective The structural and functional organization of brain networks subserving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on direct electrical stimulation (DES), a well-validated tool for the exploration of cerebral processing and for performing safe surgical interventions in eloquent areas. Methods We collected 1162 cortical and 659 subcortical DES responses during testing of 16 functional domains in 256 patients undergoing awake surgery. Spatial coordinates for each functional response were calculated, and probability distributions for the entire patient cohort were mapped onto a standardized three-dimensional brain template using a multinomial statistical analysis. In addition, matching analyses were performed against prior established anatomy-based cortical and white matter (WM) atlases. Results The probabilistic maps for each functional domain were provided. The topographical analysis demonstrated a wide spatial distribution of cortical functional responses, while subcortical responses were more restricted, localizing to known WM pathways. These DES-derived data showed reliable matching with existing cortical and WM atlases as well as recent neuroimaging and neurophysiological data. Conclusions We present the first integrated and comprehensive cortical-subcortical atlas of structures essential for humans’ neural functions based on highly-specific DES mapping during real-time neuropsychological testing. This novel atlas can serve as a complementary tool for neuroscientists, along with data obtained from other modalities, to improve and refine our understanding of the functional anatomy of critical brain networks.
Databáze: OpenAIRE
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