Electrodiagnostic Assessment of Hyperexcitable Nerve Disorders
| Autor: | Taylor B. Harrison, Spencer Kristian Hutto |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Neuromyotonia business.industry musculoskeletal neural and ocular physiology Proteins Severe disease Neuromuscular Diseases Muscle stiffness medicine.disease Autonomic nervous system Peripheral nerve Cramp fasciculation syndrome medicine Humans Continuous muscle fiber activity Isaacs Syndrome Neurology (clinical) Myokymia business Autoantibodies |
| Zdroj: | Neurologic Clinics. 39:1083-1096 |
| ISSN: | 0733-8619 |
| DOI: | 10.1016/j.ncl.2021.06.009 |
| Popis: | Peripheral nerve hyperexcitability (PNH) typically presents with complaints of muscle twitching, cramps, and muscle stiffness. Symptoms and signs indicating central and/or autonomic nervous system dysfunction also may be reported. An electroclinical spectrum exists, spanning from the milder cramp-fasciculation syndrome to more severe syndromes characterized by continuous muscle fiber activity. It is important to recognize that PNH may be an autoimmune phenomenon associated with antibodies targeting proteins of the voltage-gated potassium channel-complex and, in some patients, a paraneoplastic phenomenon. Symptomatic therapies include medicines that reduce neuronal excitability and in severe disease immunomodulatory treatments may be indicated. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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