Natural killer cells in inflammatory autoimmune diseases
| Autor: | Cynthia Louis, Yuyan Yang, Jessica Day, Fernando Souza Fonseca Guimaraes, Ian P. Wicks |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
rheumatoid arthritis lcsh:Immunologic diseases. Allergy Chemokine idiopathic inflammatory myopathies Immunology Population autoimmune disease Disease multiple sclerosis 03 medical and health sciences 0302 clinical medicine Immune system systemic lupus erythematosus Special Feature Review medicine Immunology and Allergy education General Nursing Autoimmune disease education.field_of_study natural killer cells biology business.industry Multiple sclerosis Innate lymphoid cell medicine.disease 030104 developmental biology Rheumatoid arthritis biology.protein business lcsh:RC581-607 type 1 diabetes mellitus 030215 immunology |
| Zdroj: | Clinical & Translational Immunology, Vol 10, Iss 2, Pp n/a-n/a (2021) Clinical & Translational Immunology |
| ISSN: | 2050-0068 |
| Popis: | Natural killer (NK) cells are a specialised population of innate lymphoid cells (ILCs) that help control local immune responses. Through natural cytotoxicity, production of cytokines and chemokines, and migratory capacity, NK cells play a vital immunoregulatory role in the initiation and chronicity of inflammatory and autoimmune responses. Our understanding of their functional differences and contributions in disease settings is evolving owing to new genetic and functional murine proof‐of‐concept studies. Here, we summarise current understanding of NK cells in several classic autoimmune disorders, particularly in rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1DM), but also less understood diseases such as idiopathic inflammatory myopathies (IIMs). A better understanding of how NK cells contribute to these autoimmune disorders may pave the way for NK cell‐targeted therapeutics. In this review, we summarise current understanding of NK cells in several classic autoimmune disorders, particularly in rheumatoid arthritis (RA), multiple sclerosis (MS), systemic lupus erythematosus (SLE) and type 1 diabetes mellitus (T1DM), but also less understood diseases such as idiopathic inflammatory myopathies. We also discuss how a better understanding of the contribution of NK cells to these autoimmune disorders may pave the way for NK cell‐targeted therapeutics. |
| Databáze: | OpenAIRE |
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