Conundrum of vitamin D on glucose and fuel homeostasis
| Autor: | Ken C. Chiu, Maria Mercedes Chang Villacreses, Rudruidee Karnchanasorn, Panadeekarn Panjawatanan, Horng Yih Ou |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Calcium metabolism
Vitamin Glucose metabolism medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Beta cell function Review Carbohydrate metabolism Insulin sensitivity medicine.disease chemistry.chemical_compound Diabetes mellitus Endocrinology chemistry Internal medicine Internal Medicine Vitamin D and neurology medicine Endocrine system Vitamin D business Homeostasis Hormone |
| Zdroj: | World Journal of Diabetes |
| ISSN: | 1948-9358 |
| DOI: | 10.4239/wjd.v12.i9.1363 |
| Popis: | As an endocrine hormone, vitamin D plays an important role in bone health and calcium homeostasis. Over the past two decades, the non-calcemic effects of vitamin D were extensively examined. Although the effect of vitamin D on beta cell function were known for some time, the effect of vitamin D on glucose and fuel homeostasis has attracted new interest among researchers. Yet, to date, studies remain inconclusive and controversial, in part, due to a lack of understanding of the threshold effects of vitamin D. In this review, a critical examination of interventional trials of vitamin D in prevention of diabetes is provided. Like use of vitamin D for bone loss, the benefits of vitamin D supplementation in diabetes prevention were observed in vitamin D-deficient subjects with serum 25-hydroxyvitamin D < 50 nmol/L (20 ng/mL). The beneficial effect from vitamin D supplementation was not apparent in subjects with serum 25-hydroxyvitamin D > 75 nmol/L (30 ng/mL). Furthermore, no benefit was noted in subjects that achieved serum 25-hydroxyvitamin D > 100 nmol/L (40 ng/mL). Further studies are required to confirm these observations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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