Experimental infection with the hookworm, Necator americanus, is associated with stable gut microbial diversity in human volunteers with relapsing multiple sclerosis

Autor: Gary Telford, Cris S. Constantinescu, Cinzia Cantacessi, Riccardo Scotti, David I. Pritchard, Timothy P. Jenkins, Marina Papaiakovou, Radu Tanasescu, Alba Cortés
Přispěvatelé: Cantacessi, Cinzia [0000-0001-6863-2950], Apollo - University of Cambridge Repository
Rok vydání: 2021
Předmět:
Hookworm
Multiple Sclerosis
QH301-705.5
Bacterial richness
Necator americanus
Physiology
Plant Science
Biology
Gut flora
Bacterial 16S rRNA sequencing
General Biochemistry
Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
Recurrence
Structural Biology
RNA
Ribosomal
16S
medicine
Animals
Humans
Helminths
Anthelmintic
Biology (General)
Relapse
Ecology
Evolution
Behavior and Systematics
030304 developmental biology
Autoimmune disease
0303 health sciences
Multiple sclerosis
Cell Biology
Parabacteroides
medicine.disease
biology.organism_classification
Pathophysiology
Gastrointestinal Microbiome
Bacterial diversity
Relapsing multiple sclerosis
Immunology
Helminth therapy
General Agricultural and Biological Sciences
030217 neurology & neurosurgery
Research Article
Developmental Biology
Biotechnology
medicine.drug
Zdroj: BMC Biology, Vol 19, Iss 1, Pp 1-17 (2021)
BMC Biology
ISSN: 1741-7007
DOI: 10.1186/s12915-021-01003-6
Popis: Funder: MS Society
Funder: Isaac Newton Trust; doi: http://dx.doi.org/10.13039/501100004815
Background: Helminth-associated changes in gut microbiota composition have been hypothesised to contribute to the immune-suppressive properties of parasitic worms. Multiple sclerosis is an immune-mediated autoimmune disease of the central nervous system whose pathophysiology has been linked to imbalances in gut microbial communities. Results: In the present study, we investigated, for the first time, qualitative and quantitative changes in the faecal bacterial composition of human volunteers with remitting multiple sclerosis (RMS) prior to and following experimental infection with the human hookworm, Necator americanus (N+), and following anthelmintic treatment, and compared the findings with data obtained from a cohort of RMS patients subjected to placebo treatment (PBO). Bacterial 16S rRNA high-throughput sequencing data revealed significantly decreased alpha diversity in the faecal microbiota of PBO compared to N+ subjects over the course of the trial; additionally, we observed significant differences in the abundances of several bacterial taxa with putative immune-modulatory functions between study cohorts. Parabacteroides were significantly expanded in the faecal microbiota of N+ individuals for which no clinical and/or radiological relapses were recorded at the end of the trial. Conclusions: Overall, our data lend support to the hypothesis of a contributory role of parasite-associated alterations in gut microbial composition to the immune-modulatory properties of hookworm parasites.
Databáze: OpenAIRE
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