Characterization of gels and films produced from Pinhão seed coat nanocellulose as a potential use for wound healing dressings and screening of Its compounds towards antitumour effects
| Autor: | Tielidy A. de M. de Lima, Gabriel Goetten de Lima, Bor Shin Chee, Jeferson G. Henn, Yvonne J. Cortese, Mailson Matos, Cristiane V. Helm, Washington L. E. Magalhães, Michael J. D. Nugent |
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| Přispěvatelé: | Technological University of the Shannon Midlands Midwest, This study was financed in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001 and President Seed Fund—Ireland., TIELIDY A. DE M. DE LIMA, Technological University of the Shannon, GABRIEL GOETTEN DE LIMA, Technological University of the Shannon, BOR SHIN CHEE, Technological University of the Shannon, JEFERSON G. HENN, Technological University of the Shannon, YVONNE J. CORTESE, Technological University of the Shannon, MAILSON MATOS, Bolsista da Embrapa Florestas, CRISTIANE VIEIRA HELM, CNPF, WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF, MICHAEL J. D. NUGENT, Technological University of the Shannon. |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice) Empresa Brasileira de Pesquisa Agropecuária (Embrapa) instacron:EMBRAPA Polymers; Volume 14; Issue 14; Pages: 2776 |
| Popis: | The reuse of agro-industrial waste assumes great importance today. Pinhão is the seed of Araucaria angustifolia, which is native to the mountains of southern Brazil, Paraguay, and Argentina. The coat is a by-product of this seed and is rich in phenolic compounds. The present study aimed to use the residue as a precursor material for the production of nanocellulose through the mechanical defibrillation process and perform the characterization of the films and the gel to investigate the effect on the physical and regenerative properties when incorporated with polyvinyl alcohol (PVA). The modulus of elasticity was higher when the MFC of pinhão was added to the PVA. Film and gel had their cytotoxicity tested by MTT assay using 3T3 fibroblast and Schwann cancer cells, and a migration assay was also performed using the scratch test on HaCat keratinocyte cells. For the scratch test, film and gel samples with low concentration presented a complete scratch closure in 72 h. Molecular docking was performed and quercetin had the ideal interaction score values, so it was used with the PACAP protein which presented a slightly moderate interaction with the protein synthesis of Schwann cells, presenting compactness of the compound after 14 ns. Made available in DSpace on 2022-07-26T14:20:05Z (GMT). No. of bitstreams: 1 Polymers-2022-CharacterizationGelsFilmsProducedPinhaoSeed.pdf: 3187697 bytes, checksum: b9d34e5739a688a233caeb57ea11814b (MD5) Previous issue date: 2022 |
| Databáze: | OpenAIRE |
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