HIV-2 CRF01_AB: First Circulating Recombinant Form of HIV-2
| Autor: | Shiro Ibe, Motohiro Hamaguchi, Teiichiro Shiino, Seiichiro Fujisaki, Naoto Mamiya, Junko Hattori, Rie Tanaka, Makoto Utsumi, Yasumasa Iwatani, Shingo Kato, Yoshiyuki Yokomaku, Wataru Sugiura |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Gene Expression Regulation Viral Male Most recent common ancestor Human Immunodeficiency Virus Proteins Molecular Sequence Data HIV Infections Biology Genome Virus law.invention Japan law Phylogenetics Genotype Humans Pharmacology (medical) Gene Phylogeny Genetics Molecular Epidemiology Base Sequence Molecular epidemiology virus diseases Viral Load Virology Infectious Diseases HIV-2 Recombinant DNA Female Reassortant Viruses |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 54:241-247 |
| ISSN: | 1525-4135 |
| Popis: | Background Five HIV-2-seropositive cases were recently identified in Japan, outside the HIV-2 endemic area of West Africa. To clarify the molecular epidemiology of HIV-2 in Japan, we analyzed sequences of these cases in detail. Methods HIV-2 genetic groups were determined by gag and env sequences. For suspected recombinant isolates, the genetic structure was determined by full-length genomic analyses. To understand the history and evolution of HIV-2 recombinant isolates, we estimated the time of most recent common ancestor by Bayesian Markov chain Monte Carlo method. Results Three isolates were determined as recombinants of groups A and B, and their mosaic genome structures were identical with that of 7312A, a recombinant isolate reported in 1990 from Cote d'Ivoire. Our 3 isolates and 7312A fulfilled the criteria for determining a circulating recombinant form (CRF). These isolates were verified by the Los Alamos HIV sequence database as the first CRF of HIV-2, HIV-2 CRF01_AB. The mean time of most recent common ancestor of CRF01_AB was estimated as between 1964 and 1973, several decades after the estimated emergence of HIV-2. Conclusions We recently identified HIV-2 CRF01_AB cases in Japan. This ectopic observation of the virus outside its original endemic area suggests an ongoing global spread of HIV-2 CRF01_AB. |
| Databáze: | OpenAIRE |
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