Bioactive A-type proanthocyanidins from Cinnamomum cassia
| Autor: | Penggao Duan, Matthew H. Davey, K. Brian Killday, Jan A. Glinski, Ravikanth Veluri, Michael S. Tempesta, Gloria Proni, F. Joseph Daugherty |
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| Rok vydání: | 2011 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Analytical Chemistry Tetramer Cassia Drug Discovery Proanthocyanidins Nuclear Magnetic Resonance Biomolecular Pharmacology biology Cyclooxygenase 2 Inhibitors Molecular Structure Chemistry Organic Chemistry Cinnamomum aromaticum biology.organism_classification In vitro Complementary and alternative medicine Biochemistry Proanthocyanidin visual_art visual_art.visual_art_medium Plant Bark Molecular Medicine Bark Two-dimensional nuclear magnetic resonance spectroscopy Cinnamomum |
| Zdroj: | Journal of natural products. 74(9) |
| ISSN: | 1520-6025 |
| Popis: | Two trimeric proanthocyanidins, cinnamtannin B-1 (1) and cinnamtannin D-1 (2), have been isolated from the bark of Cinnamomum cassia along with the known tetramer parameritannin A-1 (3) and a previously unreported tetramer, named cassiatannin A (4). The structures of 1-4 were elucidated on the basis of 1D and 2D NMR, MS, and CD analyses and compared to the reported data. Proanthocyanidins (1-4) possess significant in vitro inhibitory activity against cyclooxygenase-2 (COX-2) at micromolar concentrations. |
| Databáze: | OpenAIRE |
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