Synthetic hydrogen bonding receptors as models of transacylase enzymes

Autor:	Vrej Jubian, Andrew D. Hamilton, Paolo Tecilla
Přispěvatelé:	Tecilla, Paolo, Vrej, Jubian, Andrew D., Hamilton
Jazyk:	angličtina
Rok vydání:	1995
Předmět:	chemistry.chemical_classification Stereochemistry Hydrogen bond Organic Chemistry legami ad idrogeno Biochemistry Enzyme Nucleophile Thiolysis chemistry Synthetic Receptors Drug Discovery Thiol chimica supramolecolare catalisi Binding site Receptor
Popis:	A family of synthetic receptors has been prepared containing a barbiturate binding site and an appended thiol nucleophile. These are shown to cause large accelerations in the thiolysis reactions of barbiturate active ester derivatives. The size of the acceleration is shown to depend critically on the length and flexibility of the spacer that links the thiol to the receptor.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a33c1caf801c0761d0d0dc0b314e9ced http://hdl.handle.net/11368/2562854 Zobrazit plný text záznamu