Fibrinogen Kawaguchi: an abnormal fibrinogen characterized by defective release of fibrinopeptide A
| Autor: | Michio Matsuda, Shun-ichiro Manabe, Ayatsugu Kasamatsu, Chizuko Nakamikawa, Yuji Samejima, Eiji Saeki |
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| Rok vydání: | 1985 |
| Předmět: |
Ancrod
Adult medicine.medical_specialty Fibrinopeptide B Fibrinopeptide A Thrombin Time Fibrinogen Fibrin Fibrinogen Degradation Products Thrombin Internal medicine medicine Humans Amino Acid Sequence Dysfibrinogenemia chemistry.chemical_classification Fibrin Hemostasis Fibrinogens Abnormal Heterozygote advantage Hematology Blood Coagulation Disorders medicine.disease Amino acid Pedigree Endocrinology chemistry Biochemistry Female medicine.drug |
| Zdroj: | Thrombosis research. 37(3) |
| ISSN: | 0049-3848 |
| Popis: | A congenital dysfibrinogenemia was found in a 32-year-old asymptomatic female and her immediate family. The propositus, apparently a heterozygote for the abnormality, characteristically showed defective release of fibrinopeptide A from half of her fibrinogen molecules. No fibrinopeptide A was cleaved off from the isolated abnormal molecule by thrombin or snake venoms (Reptilase and Ancrod) as evidenced by radio-immunoassay, high performance liquid chromatography and determination of the NH 2 -terminal amino acids. The abnormal fibrinogen formed a solid gel solely by the release of fibrinopeptide B upon incubation with thrombin. We provisionally designate this abnormal fibrinogen as “Fibrinogen Kawaguchi”, although possible identity with other abnormal fibrinogens is not excluded. |
| Databáze: | OpenAIRE |
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