Factors associated with distant metastasis in pediatric thyroid cancer: evaluation of the SEER database
| Autor: | Wen Zeng, Ling Zhou, Min Wang, Wei Zhou, Wei Wei, Zeming Liu, Haifeng Feng, Di Hu, Danyang Chen, Yihui Huang, Liang Guo, Chao Zhang, Sichao Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
medicine.medical_specialty Multivariate analysis Endocrinology Diabetes and Metabolism Seer database Age at diagnosis 030209 endocrinology & metabolism lcsh:Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Endocrinology children distant metastasis Internal medicine endocrine malignant tumor Internal Medicine medicine thyroid cancer Pathological Thyroid cancer Univariate analysis lcsh:RC648-665 business.industry Research Distant metastasis medicine.disease 030220 oncology & carcinogenesis business |
| Zdroj: | Endocrine Connections, Vol 8, Iss 2, Pp 78-85 (2019) Endocrine Connections |
| ISSN: | 2049-3614 |
| Popis: | Objectives Controversies regarding factors associated with distant metastasis in pediatric thyroid cancer remain among the scientific community. The aim of this study was to investigate factors influencing distant metastasis in pediatric thyroid cancer. Methods We reviewed 1376 patients (aged 2 to 18 years) with thyroid cancer treated between 2003 and 2014. Data collected and analyzed included sex, race, age at diagnosis, year of diagnosis, pathological type, number of tumor foci, tumor extension, T-stage, N-stage, surgical procedure and radiation. Univariate and multivariate analyses were conducted to evaluate factors influencing distant metastasis of pediatric thyroid cancer. Results In the univariate analysis, factors influencing distant metastasis of thyroid cancer were age at diagnosis (P P P = 0.003), tumor extension (P P = 0.803), T3 (P P P = 0.001), N-stage (P P = 0.036) and T4 (P P > 0.05). Furthermore, according to chi-squared test, younger pediatric thyroid cancer patients with higher T- and N-stages are more likely to have distant metastasis. Conclusion Age at diagnosis, T-stage and N-stage influence distant metastasis of thyroid cancer patients aged 2 to 18 years; accordingly, more radical treatments may need to be used for patients with those risk elements. |
| Databáze: | OpenAIRE |
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