Impact of Hypothyroidism on Echocardiographic Characteristics of Patients With Heart Valve Disease: A Single-Center Propensity Score-Based Study

Autor: Zhenqin Cai, Yan Ling, Jiayu Zheng, Tianyu Zhai
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
endocrine system
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Heart Valve Diseases
Cardiomegaly
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
Endocrinology
0302 clinical medicine
echocardiographic characteristics
Internal medicine
medicine.artery
propensity score (PS)
medicine
Left atrial enlargement
Humans
Euthyroid
heart valve disease (HVD)
Interventricular septum
Heart valve
Propensity Score
Aged
Retrospective Studies
Original Research
Ejection fraction
lcsh:RC648-665
business.industry
Retrospective cohort study
Middle Aged
medicine.disease
left atrial enlargement
030104 developmental biology
medicine.anatomical_structure
Blood pressure
Echocardiography
Pulmonary artery
Cardiology
Female
hypothyroidism
business
hormones
hormone substitutes
and hormone antagonists
Zdroj: Frontiers in Endocrinology, Vol 11 (2020)
Frontiers in Endocrinology
ISSN: 1664-2392
Popis: Background: Hypothyroidism is known to be correlated with multiple heart diseases. However, the influence of hypothyroidism on the patients with heart valve disease (HVD) is still unclear. The purpose of our study was to investigate the impact of hypothyroidism on echocardiographic characteristics of patients with heart valve disease. Methods: We conducted a retrospective cohort study which included 2,128 patients with HVD, and they were divided into euthyroid, subclinical hypothyroidism (SCHypoT), and overt hypothyroidism (OHypoT) group. Echocardiographic characteristics before and after valve surgery between groups were compared by using propensity score (PS) analysis. Kaplan–Meier analysis was used to compare the percent of recovery of left atrial (LA) enlargement between groups. Results: Overall, 463 patients had hypothyroidism (404 SCHypoT patients and 59 OHypoT patients), and 1,665 patients were euthyroid. At baseline, hypothyroidism was associated with significantly higher left atrial diameter (LAD), interventricular septum thickness, left ventricular posterior wall thickness, pulmonary artery systolic pressure, and lower left ventricular ejection fraction. After valve surgery, only LAD remained significantly higher in the patients with hypothyroidism. Additionally, patients with hypothyroidism had a significantly lower recovery rate of LA enlargement after valve surgery compared with euthyroid patients. Conclusion: Hypothyroidism was associated with a larger LAD in patients with HVD before and after surgery, which may suggest that hypothyroidism is a risk factor of LA enlargement of HVD. Besides, hypothyroidism was associated with a significantly lower recovery rate of LA enlargement after valve surgery.
Databáze: OpenAIRE
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