Sputum Itraconazole Concentrations in Cystic Fibrosis Patients
| Autor: | Patrick Berche, Christophe Hennequin, Gérard Lenoir, Isabelle Sermet-Gaudelus, E. Singlas, A. Lesne-Hulin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Adolescent
Cystic Fibrosis Itraconazole Microbial Sensitivity Tests Aspergillosis Cystic fibrosis Aspergillus fumigatus fluids and secretions Pharmacokinetics medicine Humans Pharmacology (medical) Child Mycosis Pharmacology biology business.industry Aspergillosis Allergic Bronchopulmonary Sputum medicine.disease biology.organism_classification respiratory tract diseases Infectious Diseases Child Preschool Immunology Allergic bronchopulmonary aspergillosis medicine.symptom business medicine.drug |
| Popis: | Itraconazole diffusion in sputum was studied in 11 cystic fibrosis patients with allergic bronchopulmonary aspergillosis. There was a high interindividual variability in sputum itraconazole concentration and sputum/serum drug concentration ratio. Three children had sputum drug concentrations before oral administration that were lower than the itraconazole MIC at which 90% of Aspergillus fumigatus strains were inhibited, although their serum drug concentrations were within the therapeutic range. |
| Databáze: | OpenAIRE |
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