Extracellular Matrix Changes in Stented Human Coronary Arteries
| Autor: | Kirubel Tefera, Frank D. Kolodgie, Allen P. Burke, Renu Virmani, Thomas N. Wight, Deena K. Weber, Andrew Farb, Jin-Yong Hwang |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Neointima Pathology medicine.medical_specialty Time Factors Decorin Myocytes Smooth Muscle Cell Count Coronary Restenosis Extracellular matrix Versicans Restenosis Physiology (medical) Biglycan medicine Animals Humans Protein Isoforms Lectins C-Type Hyaluronic Acid Selection Bias Aged Extracellular Matrix Proteins Wound Healing biology business.industry Middle Aged equipment and supplies medicine.disease Extracellular Matrix Rats Surgery Coronary arteries Hyaluronan Receptors medicine.anatomical_structure Chondroitin Sulfate Proteoglycans Postmortem Changes biology.protein Versican Female Proteoglycans Stents Collagen Tunica Intima Cardiology and Cardiovascular Medicine Wound healing business |
| Zdroj: | Circulation. 110:940-947 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.0000139337.56084.30 |
| Popis: | Background— Restenosis after stenting occurs secondary to the accumulation of smooth muscle cells (SMCs) and extracellular matrix (ECM), with the ECM accounting for >50% of the neointimal volume. The composition of the in-stent ECM has not been well characterized in humans. Methods and Results— Postmortem human coronary arteries (n=45) containing stents underwent histological assessment of neointimal proteoglycans, hyaluronan, collagen (types I and III), SMCs, and CD44 (a cell surface receptor for hyaluronan). The mean duration of stent implantation was 18.7 months; stents in place ≥3 to Conclusions— The ECM within human coronary stents resembles a wound that is not fully healed until 18 months after deployment, followed by neointimal retraction. ECM contraction may be a target for therapies aimed at stent restenosis prevention. |
| Databáze: | OpenAIRE |
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