Long-Term Outcome of Renal Transplantation in Autosomal Dominant Polycystic Kidney Disease
| Autor: | Keith E. Holley, Horst Zincke, Kenneth P. Offord, Peter M. Fitzpatrick, Vicente E. Torres, J. William Charboneau |
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| Rok vydání: | 1990 |
| Předmět: |
Adult
Male medicine.medical_specialty Autosomal dominant polycystic kidney disease Urology Chromosome Disorders Autopsy Kidney urologic and male genital diseases Recurrence medicine Polycystic kidney disease Humans Longitudinal Studies Survival rate Kidney transplantation Genes Dominant Cause of death Chromosome Aberrations Polycystic Kidney Diseases Cysts urogenital system business.industry Liver Diseases Middle Aged medicine.disease Kidney Transplantation female genital diseases and pregnancy complications Surgery Survival Rate Transplantation medicine.anatomical_structure Nephrology Female Tomography X-Ray Computed business |
| Zdroj: | American Journal of Kidney Diseases. 15:535-543 |
| ISSN: | 0272-6386 |
| DOI: | 10.1016/s0272-6386(12)80523-3 |
| Popis: | This study was performed to determine the long-term outcome of renal transplantation in 54 patients with end-stage renal failure secondary to autosomal dominant polycystic kidney disease (ADPKD) and in 107 patients with renal diseases other than ADPKD or diabetes mellitus matched by gender, age, year of transplantation, and source of the allograft. The overall patient survival and patient survival with a functioning first renal allograft were similar in both groups. Infection and cardiovascular accidents were the leading causes of early and late death in both groups. No cause of death was greatly overrepresented in the ADPKD group. Serious complications from extrarenal manifestations of ADPKD following renal transplantation included a ruptured intracranial aneurysm in one patient, a dissection of the ascending thoracic aorta in one patient, and infected hepatic cysts in two patients. Neoplasia (other than skin or cervical) occurred in four ADPKD patients and in one control patient and included one lymphoma in each group. Two ADPKD and one control patient had monoclonal gammopathies of undetermined significance. No complications related to the retention of native kidneys were detected in 12 ADPKD patients with a mean follow-up of 3 years. Cysts were observed in the renal allografts of some patients in both groups at autopsy and in a prospective computed tomography (CT) study of the allograft. However, we failed to detect a significant difference in the occurrence and number of the cysts between ADPKD and control patients. |
| Databáze: | OpenAIRE |
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