In vitro methods to assess drug precipitation
| Autor: | Wei-Guo Dai |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Drug
Chemistry Pharmaceutical Drug Compounding media_common.quotation_subject Administration Oral Pharmaceutical Science Pharmacology Pharmaceutical formulation Pharmacokinetics Oral administration In vivo Animals Chemical Precipitation Humans Technology Pharmaceutical Medicine Infusions Intravenous media_common Miniaturization Precipitation (chemistry) business.industry In vitro toxicology Equipment Design In vitro High-Throughput Screening Assays Kinetics Pharmaceutical Preparations Solubility Injections Intravenous business |
| Zdroj: | International Journal of Pharmaceutics. 393:1-16 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2010.03.040 |
| Popis: | Drug precipitation in vivo is often an undesirable outcome after administration of a drug formulation into a human body. It may reduce drug concentration for immediate action, leading to a delayed or reduced efficacy. There are few practical in vivo assays available for evaluation of drug precipitation. Effective and efficient in vitro precipitation screening assays are highly desirable. In recent years, in vitro assays for assessment of drug precipitation potential have become available. The aim of this article is to provide the reader with a brief review of such in vitro precipitation screening assays for intravenous and oral formulations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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