An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage
| Autor: | Bochu Wang, Jia Deng, Yuhua Gong, Guo Yuanyuan, Jingou Ji, Shilei Hao, Tingwang Guo |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Drug media_common.quotation_subject Nicardipine Pharmaceutical Science 02 engineering and technology Methylcellulose Pharmacology 030226 pharmacology & pharmacy Neuroprotection Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Nicardipine Hydrochloride medicine Animals Hyaluronic Acid Administration Intranasal Cerebral Hemorrhage media_common Intracerebral hemorrhage Chitosan Drug Carriers Chemistry Therapeutic effect technology industry and agriculture 021001 nanoscience & nanotechnology medicine.disease Bioavailability Drug Liberation Neuroprotective Agents Brain Injuries Nanoparticles Nasal administration 0210 nano-technology Gels medicine.drug |
| Zdroj: | International Journal of Pharmaceutics. 566:46-56 |
| ISSN: | 0378-5173 |
| Popis: | Intranasal drug delivery provided an alternative and effective approach for the intervention of an intracerebral hemorrhage (ICH). However, the short retention time at the absorption site and slow drug transport in intranasal gel influence the drug bioavailability and outcome of ICH. Herein, we fabricated a novel intranasal gel with oriented drug migration utilizing a charge-driven strategy to attenuate brain injury after ICH. Nicardipine hydrochloride (NCD) was entrapped in chitosan nanoparticles (CS NPs) and dispersed in an HAMC gel. Subsequently, one side of the gel was coated with a positively charged film. The oriented migration of CS NPs in the HAMC gel was determined, and the drug bioavailability was also enhanced. Furthermore, a blood-induced ICH rat model was established to evaluate the therapeutic effect of CS NPs + HAMC composites. Intranasal administration of the CS NPs + HAMC (+) composite showed a stronger neuroprotective effect in terms of brain edema reduction and neural apoptosis inhibition compared to the CS NPs + HAMC composite. These results suggested that the oriented and rapid drug transport from nose to brain can be achieved using the charge-driven strategy, and this intranasal drug delivery system has the potential to provide a new therapeutic strategy for the treatment of ICH. |
| Databáze: | OpenAIRE |
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