Heparin coating of small-caliber decellularized xenografts reduces macrophage infiltration and intimal hyperplasia
| Autor: | Chang-Zhi Chen, Y. John Gu, Wei-Wei Cai, Xue-Ning Wang |
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| Rok vydání: | 2009 |
| Předmět: |
VASCULAR PROSTHESES
Male Pathology medicine.medical_specialty Intimal hyperplasia PATHOGENESIS Transplantation Heterologous Biomedical Engineering Medicine (miscellaneous) Thrombogenicity Bioengineering EPTFE GRAFTS Biomaterials Blood Vessel Prosthesis Implantation In vivo INJURY medicine Animals Macrophage infiltration MUSCLE-CELL-PROLIFERATION Decellularization IN-VIVO Cell Proliferation Neointimal hyperplasia Hyperplasia Small-caliber Chemistry Heparin Xenograft Muscle cell proliferation Macrophages NEOINTIMAL HYPERPLASIA General Medicine medicine.disease Heparin coating Surgery MODEL Transplantation BYPASS PLATELET DEPOSITION Female Rabbits Tunica Intima |
| Zdroj: | ARTIFICIAL ORGANS, 33(6), 448-455. Wiley |
| ISSN: | 1525-1594 0160-564X |
| Popis: | Small-caliber decellularized xenografts with surface heparin coating are known to reduce in vivo thrombogenicity. This study was performed to examine whether heparin coating on the small-caliber decellularized xenografts would reduce macrophage infiltration and intimal hyperplasia. In a rabbit model of bilateral carotid implantation, each of the animals (n = 18) received a heparin-coated decellularized xenograft from a canine carotid artery on one side and a nonheparin-coated one on the other side. These experiments were terminated respectively at 1 week (n = 6), 3 weeks (n = 6), and 12 weeks (n = 6). Results showed that, compared with the nonheparin-coated grafts, the heparin-coated grafts had significantly less macrophage infiltration 1 week after implantation, identified by the mouse antirabbit macrophage antibody (RAM11)-positive cells on the vascular wall, covering all the proximal, middle, and distal parts of the grafts (P |
| Databáze: | OpenAIRE |
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