Associations of HLA-DR4 with rheumatoid factor and radiographic severity in rheumatoid arthritis
| Autor: | Leigh F. Callahan, Theodore Pincus, Paul Nance, Nancy J. Olsen, Raye H. Brooks, Jeremy J. Kaye, Peter Stastny |
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| Rok vydání: | 1988 |
| Předmět: |
Male
musculoskeletal diseases Heterozygote medicine.medical_specialty Activities of daily living Radiography Arthritis Immunogenetics Hla dr4 antigen Arthritis Rheumatoid Rheumatoid Factor immune system diseases Internal medicine Activities of Daily Living HLA-DR4 Antigen medicine Humans Rheumatoid factor skin and connective tissue diseases HLA-D Antigens business.industry HLA-DR Antigens General Medicine Middle Aged medicine.disease Rheumatoid arthritis Immunology Female business |
| Zdroj: | The American Journal of Medicine. 84:257-264 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(88)90422-6 |
| Popis: | Possible associations between HLA-DR4 and laboratory, radiographic, joint count, functional, and demographic measures of clinical status were analyzed in 154 white patients with rheumatoid arthritis. Overall, 65 percent of the patients were HLA-DR4 positive, similar to other series. HLA-DR4 was associated significantly with the presence of rheumatoid factor and more severe radiographic changes. HLA-DR4 was not associated with significant differences in demographic, joint count, or functional measures of clinical status. HLA-DR1 was not associated significantly with differences in the presence of rheumatoid factor, radiographic changes, or other measures of clinical status. Selective associations of HLA-DR4 with rheumatoid factor and radiographic scores were more marked in men than in women. Patients who were putatively homozygous for HLA-DR4 were all seropositive and had more severe radiographic changes than patients who were heterozygous for HLA-DR4. |
| Databáze: | OpenAIRE |
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